設(shè)計合成一個含噻二唑活性基團(tuán)的苦參堿類化合物畢業(yè)論文

1、河南科技大學(xué)畢業(yè)設(shè)計（論計（論文）文）設(shè)計合成一個含噻二唑活性基團(tuán)的苦參堿類化合物姓名黃曉博院（系）（系）林學(xué)院專業(yè)植物保護(hù)指導(dǎo)教師指導(dǎo)教師車志平徐暉教授教授2015年6月8日ABSTRACTBotanicalpesticideshavemanyadvantagessuchaslowtoxicityeasilybiodegradablesafetonontargetganismstheenvironmentdifficulttodeve

2、lopdrugresistancefpestetal.theybecomethefocusofresearchingdevelopingpesticidestoday.Withplantderivednaturalproductsasleadcompoundsmodifyingtransfmingtheirstructurestofindderivativeswhichexhibitehigheractivitiesareaveryim

3、ptantwayofdevelopingnewpesticidesbutalsothemaincurrentintheresearchareaofbotanicalpesticides.Asisknowntousallintroducingheteroatomheterocyclicintothemolecularofnaturalcompoundcanremarkablyenhanceitsbiologicalactivitieswh

4、ichisoneofthebasicapproachestofmulatenewpesticides.MatrineoneofthemainalkaloidsisextractedfromSophaflavescensachinesemedicinalherbsitiswidelyusedinthefieldsofpharmaceuticalpesticideduetoitsbroadspectrumbiologicalactiviti

5、es.Thefunctionalgroupthiadiazolehasgoodagriculturalactivitiesisgenerallyconcernedbypeople.Therefeaccdingtotheprincipleofflatteningthisstudyhasdesignedsynthesisamatrinecompoundcontaininganactivegroupofthiadiazolethroughso

6、mereactionssuchashydrolysisesterificationacylationwithplantderivednaturalproductmatrineasleadcompoundintroducingtheheterocyclicthiadiazoleintothemothercompound.Thenthestructureofthiscompoundwasacterizedby1HNMR.Theinfmati

7、onofits1HNMRshowedthatthestructureisinlinewiththeoneexpected.Becauseofmatrinemolecular’slagerpolarthereareallkindsofdifficultyintheprocessesofsynthesisseparation.Inthisstudyinadditiontopreparingthetargetcompoundthereacti