張茂俊

1、<p><b>　　張茂俊</b></p><p><b>　　一、個(gè)人簡(jiǎn)介</b></p><p>　　張茂俊 博士 研究員 博士生導(dǎo)師</p><p>　　中國(guó)疾病預(yù)防控制中心傳染病預(yù)防控制所彎曲菌疾病控制工作負(fù)責(zé)人。中華醫(yī)學(xué)會(huì)公共衛(wèi)生分會(huì)副秘書長(zhǎng)，中國(guó)生態(tài)學(xué)學(xué)會(huì)生態(tài)健康與人類生態(tài)專業(yè)委員會(huì)副秘書長(zhǎng)。主要從事

2、彎曲菌感染的疾病控制、細(xì)菌分子流行病學(xué)及群體遺傳學(xué)的研究。近五年來(lái)主持973課題1項(xiàng)，國(guó)家自然科學(xué)基金多項(xiàng)。至今表論文50余篇，獲得國(guó)家發(fā)明專利多項(xiàng)。</p><p><b>　　二、主要研究方向</b></p><p>　　目前主要研究方向?yàn)閺澢腥镜募膊】刂啤澢饶c道細(xì)菌感染致病機(jī)理的研究、細(xì)菌分子流行病學(xué)及群體遺傳學(xué)研究、病原菌感染的分子診斷技術(shù)的研發(fā)等。

3、</p><p><b>　　三、代表性科研項(xiàng)目</b></p><p>　　2011年至今，作為負(fù)責(zé)人主持973課題1項(xiàng)、國(guó)家自然科學(xué)基金面上項(xiàng)目2項(xiàng)、橫向課題1項(xiàng)；作為研究骨干參與國(guó)家及省部級(jí)課題多項(xiàng)：</p><p>　　973國(guó)家重點(diǎn)發(fā)展計(jì)劃項(xiàng)目：“禽畜重要病原菌抗生素耐藥性的形成、傳播與控制的基礎(chǔ)研究”-課題：“食源性耐藥病原菌的時(shí)空

4、分布與傳播動(dòng)力學(xué)特征”-負(fù)責(zé)人；</p><p>　　國(guó)家自然科學(xué)基金-面上項(xiàng)目：“空腸彎曲菌群體遺傳特征及菌型傳播動(dòng)力模型分析”-負(fù)責(zé)人；</p><p>　　國(guó)家自然科學(xué)基金-面上項(xiàng)目：“我國(guó)格林-巴利綜合癥暴發(fā)相關(guān)空腸彎曲菌脂多糖遺傳特異性及其致病機(jī)制分析”-負(fù)責(zé)人。</p><p>　　橫向課題：“彎曲菌檢測(cè)技術(shù)的研究”-負(fù)責(zé)人</p><

5、;p>　　代表性論文、成果（2011年以來(lái)）</p><p>　　Zhang A, Song L, Liang H, Gu Y, Zhang C, Liu X, Zhang J, Zhang M. Molecular subtyping and erythromycin resistance of Campylobacter in China. J Appl Microbiol. 2016 Jul;121(

6、1):287-293. </p><p>　　Zhang M, Gilbert M, Yuki N, Cao F, Li J, Liu H, Li Q, Meng F, Zhang J. Association of Anti-GT1a Antibodies with an Outbreak of Guillain-Barré Syndrome and Analysis of Ganglios

7、ide Mimicry in an Associated Campylobacter jejuni Strain. PLoS One. 2015 Jul 21;10(7):e0131730. </p><p>　　Fengru Deng, Jianzhong Shen, maojun zhang, Congming Wu, Qijing Zhang, and Yang Wang Constit

8、utive and Inducible Expression of the rRNA Methylase Gene erm(B) in Campylobacter Antimicrob Agents Chemother. 2015 Oct; 59(10):6661-4.</p><p>　　Zhang M, et al. Molecular Subtyping and Antimicrobia

9、l Susceptibilities of Campylobacter coli Isolates from Diarrheal Patients and Food-Producing Animals in China. Foodborne Pathog Dis. 2014 May 20. </p><p>　　Wang Y, Zhang M, Deng F, Shen

10、Z, Wu C, Zhang J, Zhang Q, Shen J. Emergence of Multidrug-Resistant Campylobacter Species Isolates with a Horizontally Acquired rRNA Methylase. Antimicrob Agents Chemother. 2014 Sep; 58(9):5

11、405-12. </p><p>　　Qin S, Wang Y, Zhang Q, Zhang M, Deng F, Shen Z, Wu C, Wang S, Zhang J, Shen J. Report of ribosomal RNA methylase gene erm(B) in multidrug-resistant Campylobac

12、ter coli.J Antimicrob Chemother. 2014 Apr; 69(4):964-8. doi: 10.1093/jac/dkt492. </p><p>　　Zhang M, et al. Development and application of a real-time polymerase chain reaction method for Campylobacter jejuni

13、 detection World J Gastroenterol 2013, 19(20):3090-3095. </p><p>　　Zhang M, et al. In vitro protein expression profile of Campylobacter jejuni strain NCTC11168 by two-dimensional gel electrophoresis and mass

14、 spectrometry Biomed Environ Sci. 2013 Jan;26(1):48-53. </p><p>　　Zhang M, et al. Genome Sequences of the Guillain-Barre Syndrome Outbreak-Associated Campylobacter jejuni Strains ICDCCJ07002 and ICDCCJ07004

15、Genome Announc. 2013 May 23;1(3). </p><p>　　Zhang M, et al. Cloning, Expression, and Antigenicity of 14 Proteins from Campylobacter jejuni. Foodborne Pathog Dis. 2012, Aug;9(8):706-12. </p><p>　

16、　Zhang M, et al. Genome Sequences of Three Helicobacter pylori Strains Isolated from Atrophic Gastritis and Gastric Ulcer Patients in China. J Bacteriol. 2012 Nov;194(22):6314-5. </p><p>　　QIAO Bo, XU Xue-bi

17、n, GU Yi-xin, LIU Guo-dong, ZHAO Fei, HE Li-hua, ZHANG Jian-zhong, ZHANG Mao-jun. Real-Time PCR development for identification of Campylobacter Coli from stool Specimen. Chinese Journal of Zoonoses, 2012, 28(10). 969-972