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1、1TheQualityStardofQuinocetoneKuixitongQuinocetoneC18H14N2O3306.32Quinocetoneiscalled3methyl2cinnamicacylquinoxalinee14dioxideinchemistry.ThecontentofC18H14N2O3isnolessthan98.0%indrying.[acter]Thedrugisyellowcrystallineam
2、phouspowderhasnoabnmalflavour.ItcouldbeeasilydissolvedinCHCl3dioxanedimethylsulfoxideslightlyinmethylalcoholethylalcoholbutnotinwater.[Meltpoint]Meltpointofthedrugis190193.0℃(basedonVeterinaryPharmacopoeiaofChinathefirst
3、supplementediton2000page34)meltingcoincidedwithdisintegration.[Identification](1)After0.2gofthedrugisweighedapproximatelydissolvedwith10mldimethylfmaecompletely2mLofthesolutionistakenouttotubethen2sof1%KMnO4solutionisadd
4、ed.OnshakingthecolourwithKMnO4fadesfuscescentsedimentemerges.(2)50mgofthedrugisaccuratelyputintoa100mLambercolouredvolumetricflask.Afterdissolvedwith10mLdioxanethesolutionisdilutedby40%dioxanetothescale.Onshakingcomplete
5、ly1mlofthesolutionismeasuredaccuratelyputinto50mLambercolouredvolumetricflask.Assayingbasedonspectrophotometricmethod(basedonVeterinaryPharmacopoeiaofChinathefirstsupplementediton2000page17)theresultsindicatethatthesolut
6、ionhasmaximumabsptionvalueat2311nm2601nm3141nmwavelength.NNOOOCH3CCHCH3carbonizationfullyat500600℃.Aftercooling5mLhydrochicacid3mlwaterareaddedindertodissolvetheresidue.Thecontentofthearsenicisnomethan2ofmillion(basedonV
7、eterinaryPharmacopoeiaofChinathefirstsupplementediton2000page56).[Assaying]Basedonhighperfmanceliquidchromatography(inVeterinaryPharmacopoeiaofChinathefirstsupplementediton2000page24).Chromatographicconditionsystemsuitab
8、ilityexperimentOctadecylsilanelinkagesilicagelisusedasbulkingagent.Methylalcoholwater(60∶40)isusedasmobilphasedetectionwavelengthis314mthenumberoftheeticalplatescalculatedwithquinocetoneisnolessthan3000.AssayingAfterthes
9、ufficientproductisweighedaccuratelyDMFisaddedto2mgofquinocetonepermL.Thesolutionisdilutedwithmethylalcoholto0.1mgmL.Then10μLofthesolutionismeasuredaccuratelyinputtochromatographofliquidthenchromatogramisrecded.Thecompari
10、sonsampleofquinocetonewithconstantweightat105℃isdeterminedastheabove.Thecontentiscalculatedwithpeakareabyexternalreferencemethod.[Effectusage]antibacterialdruggrowthpromoterinlivestockpoultry.[Directiondosage]theproducti
11、susedasafeedadditive.Per1000kgstoyerpig:50g(50ppm)adultfowl:75g(75ppm)chicken:50g(50ppm).Theadditionoftheotherfowlslivestockwasthesametotheabove.Itmustbeunifmwhenquinocetoneisaddedtostoyer.[Ste]awayfromlightcloseedtightl
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