花粉與顆粒物復(fù)合毒性效應(yīng)的研究.pdf

1、南開大學(xué)碩士學(xué)位論文花粉與顆粒物復(fù)合毒性效應(yīng)的研究姓名：葉鳳釵申請學(xué)位級別：碩士專業(yè)：環(huán)境科學(xué)指導(dǎo)教師：王玉秋20090501AbstractAbstractBackgroundParticulatematter(PM)isanimportantfactorassociatedwiththeenhancedprevalenceofrespiratoryallergyThePMadjuvantactivityonallergicsensi

2、tizationisapossiblemechanismofoxidationdamageinvolved，andtheinductionofairwayinflammationissuggestedtobeofimportanceinPMinducedadjuvantactivityObjectiveBecausedifferentPMhasdifferenttoxicpotentials，westudiedDEEToexaminep

3、ossibleinteraction，orgreaterthanadditiveresponses，betweenPMeffectsandallergicresponses，anArtemisiapollenandchallengedmousemodelofallergicairwaysdiseasewasutilizedMethodsMiceweresensitizedwith015mlArtemisiapollenin1mlinst

4、erilesalineinjectedintraperitoneallyonthefirstdayandthefifthdayControlmicereceivedsterilesalineTwentydayslaterallmicewerechallengedwithanaerosolof015mlArtemisiapollen，insterilesalinefor1hinachamberAftersensitization，mice

5、wereexposedinachamberwithDEPandair20min，30min，40minonfiveconsecutivedaysSignificantinteractionsbetweenDEPandArtemisiapollenwereobserved，especiallywithrespecttocomplianceMicewereexposedtoArtemisiapollenaloneorincombinatio

6、nwithoneofthedifferentconcentrationDEETheinductionofairwayinflammationandtheimmuneadjuvantactivitywerestudiedinthelungsandbloodResultsAstronginteractionbetweenArtemisiapollenandDEPexposureresultedinsignificantincreaLsesi

7、nMDA，SOD，GSHPXQo05)thanthatinArtemisiapollenexposurealoneSignificantinteractionswerealsofoundwithrespectto也4andIgEafterchallengeConclusionTheseresultsshowthatDEPexposurehadaadjuvanteffectonenhancementofthesensitizationBu