基于神經(jīng)核團(tuán)放電特征參數(shù)的立體定向?qū)Ш较到y(tǒng)研究.pdf

1、南京航空航天大學(xué)碩士學(xué)位論文基于神經(jīng)核團(tuán)放電特征參數(shù)的立體定向?qū)Ш较到y(tǒng)研究姓名：曹清華申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：生物醫(yī)學(xué)工程指導(dǎo)教師：錢志余20090301基于神經(jīng)核團(tuán)放電特征參數(shù)的立體定向?qū)Ш较到y(tǒng)研究iiABSTRACTStereotaticlocalizationisthekeytechnologyftargetlocatinginneurosurgeryfParkinson’sdisease.Accdingtotheclinicde

2、mofMERbasedstereotaticneurosurgerythisstudyisbasedonmicroelectrodedataofParkinson’sdisease.Signaldisposingarithmeticisproposedbytheacteristicalanalyzingofclinicdata.Thegoalistoextractthepositionreferringparametersofneuro

3、naldisgesignals.Thenappliedsoftwarefidentifyingbrainstructuretissuesisdevelopedbyusingseveralsignaldisposingarithmetics.Thissoftwarecanbeusedasarealtimeassistanttoolfjudgingpositionofelectrode’spinpointidentifyingneurona

4、ltissuesthemainapplicationistargetlocatinginneurosurgery.Throughindepthresearchingmuchexperimenttheparticulararithmeticsofstereotaticlocalizationsystemdesignaregiveninthisthesisstepbystep.Themainachievementsinnovativeres

5、ultsaredescribedinthefollowingparts.1.AtheywhichconsistsoftheEmpiricalModeDecompositionarithmeticthethresholddetectiontheeticsisintroducedtoseekthedetectingthresholdofhumanneurondisgesignalswhichhaveactersofelectrophysio

6、logicalsignalsuchastimedependentnonlinearfaintstronginterference.thismethodcangettheacteristicgenewhichisreferringtothelocalneurontissue.2.Basedontheelectrophysiologicaltargetlocalizationtechnologyacteristicalgenes’arith

7、meticappliedsoftwarewhichaimsatlocatingtargetinstereotaticlocalizationneurosurgeryisdevelopedbyusingobjectienteddevelopingtools.Thissoftwarecanassistclinicneurosurgery.It’saneffectiveassistanttoolitprovidesanewmethodinre

8、solvingtheproblemofneuronaltissuerecognizationtargetlocalization.3.Anintegratedarithmeticisappliedtogettheaverageparameterofseveralunitaryacteristicalgenesaccdingtotheanalysisofseveralsignaldisposingmethodsitsresults.Thi

9、smethodcanbeusedtoimprovetherecognizingprecisionofneuronaltissuesuchasGlobusPallidus.TheappliedsoftwarewhichisbasedonthetheiesofboxdimentiondetectionthresholdenergyofHilbertHuangtransfmsignalsenergymodulationcancalculate

10、thoseparameterssimultaneouslyeffectivelyquicklyitrealizesthecontradistinctiveanalysisfunction.Keywds:Parkinson’sdiseasemicroelectroderecdingelectrophysiologyanalysisneuronaldisgestereotaticlocalizationganizationrecogniza