人腦膠質(zhì)瘤中CD133、神經(jīng)巢蛋白的表達及其意義.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文人腦膠質(zhì)瘤中CD133、神經(jīng)巢蛋白的表達及其意義姓名：聶曉冬申請學(xué)位級別：碩士專業(yè)：神經(jīng)外科學(xué)指導(dǎo)教師：范益民20080520山西醫(yī)科大學(xué)碩士學(xué)位論文TheexpressionofCD133andNestininhumangliomaanditsclinical●●，Sl丹ll：[1cancesAbs仃actObjective：ToexploretheexpressionofCDl33andnestininhum

2、angliomacellofthepatientswithneurogliocytomaandtoseewhetherornotCD133andnestinexpressionassociatewiththedifferentiationandpathologicgradingItwasexpectedthatthisstudycouldrevealsomeessentialqualitiesofthegliomaandprovidep

3、otentialapplicationforjudgingthemalignantgradesandbiologicaltreatmentMethods：TheexpressionofCDl33andnestinwasdetectedin65casesofhumangliomaand19specimensofnormalbraintissuesbyimmunohistochemistrystainingResults：①Theposit

4、ivecellratesoftheCDl33expressionwere1846％inhumangliomasamplesandO％inthecontrolgroup(Po01)，andnestinwererespectively2379％and516％(P001)②ThepositivecellratesofCDl33ornestinvariedaccordinglytodifferentpathologicalgradesThere

5、weresignificantdifferencebetweengradeIandgradeⅢorgradeⅣ∽001)ThereweredifferencebetweengradeIIandgradeⅢorgradeⅣ儼o01)ThesamesignificancewerealsofoundbetweengradeⅢandgradeIV(尸o01)Thehigherpathologicalgradeshadhigherpositive

6、cellrates@ThereweresignificantdifferencebetweenthepositiveceilratesofCDl33groupandnestingroup職005)TheexpressionsofCDl33groupwerelowerthannestingroupThereWasasignificantcorrelationbetweenCDl33groupandnestingroup(r=O408，P0

7、05)Conclusion：ThepositivecorrelationexistedbetweentheexpressionofCD133ornestinandthepathologicalgradingofthehumangliomaDetectingCD133andnesfininthehumangliomacailbeusedindiagnosing，judgingthemalignancydegreeandtheprognos