靜電紡PLA、PLGA及絲素纖維膜的降解性能研究.pdf

1、蘇州大學碩士學位論文靜電紡PLA、PLGA及絲素纖維膜的降解性能研究姓名：王立新申請學位級別：碩士專業(yè)：紡織材料與紡織品設計指導教師：張幼珠20090401靜電紡PLA、PLGA及絲素纖維膜的降解性能研究AbstractStudyondegradationofelectrospunPLA、PLGAandsilkfibermembranesAbstractTheelectrospinningtechniqueisoneofthemosti

2、mportantmethodsofproducingcontinuousnanofiberswithdiameterrangefromseveralmicrometerstOtensofnanometersWithsmalldiameterhighsurfaceareatovolumeratioandhighporositynanofiberCanbeusedintissueengineeringandbiomedicalenginee

3、ringInthispaperthreedegradablematerials，PLA、PLGAandSF(silkfibroin)wereelectedtOelectrospinandstudiedonthedegradationofthemdetailedlyThroughthemembranesoftheweightloss，molecularweight，breakingintensityandSEMobservationoft

4、hechangesinmorphologymeanwhilethroughXraydiffractionandDTAtestingintheprocessofdegradationofcrystalchanges，thedegradationofthreetypesoffbermembranesperformancewerecharacterizedOurgrouphasstudiedtheconditionsofelectrospun

5、PLA，PLAmembraneswereobtainedonthisbasis，andthenimmersedinPBSsolutiontodegradateThemolecularweightofthefirsttwoweeksdeclinedsignificantlyandfasterthantherateofweightlossandbreakingintensityThefiberswereunevenandbrokeninth

6、edegradationof16weeksDuringthedegradationprocess，crystalofsamplesdecreasedgraduallyBeforestudyingthedegradationofPLGAmembrane，firstly，theeffectofconcentration、voltageanddistanceonthemorphologyandstructureofthePLGAfibersw

7、erestudiedTheoptimumconditionswereasfollows：theconcentrationof7％，voltage20kV，distance13cmPLGAmembraneswereimmersedinPBSsolutiontodegradateDegradationofPLGAmembraneswasfasterthanPLAmembranesThereisarapidincreaseinweightlo

8、ssandthemolecularweightreductionintwoweeks，buttheweightlossrateisstilllaggingbehindthedeclineinthemolecularweightreductionAtthesametime，thefibershavebeensomefracture，breakingintensitydecreasedrapidlyThefibersdisappearedi