鈦合金表面活化與HAP生物涂層的制備及性能研究.pdf

1、蘭州大學(xué)碩士學(xué)位論文鈦合金表面活化與HAP生物涂層的制備及性能研究姓名：張東申請學(xué)位級別：碩士專業(yè)：口腔臨床醫(yī)學(xué)指導(dǎo)教師：劉斌王金清20100501ABSTRACTTitanium(Ti)alloyiswidelyusedasdentalimplantmaterialduetoitsgoodbiocompatibilityHowever，itshouldbenotedthatthereisaseriouscorrosionoccurre

2、dafterlong—termapplicationTherefore，TialloyshouldbemodifiedbeforeuseforimprovingitsimplantingbehaviorInthisthesis，thecorrosionperformanceofTialloyinartificialsaliva(AS)，salinesolution(NS)，simulatingbodyfluid(SBF)wasfirst

3、lyinvestigatedbyelectrochemicalmethodTialloywasbioactiveafterpretreatmentbymicroarcoxide(MAO)ortheimprovedalkali—heat(IAH)treatmentThen，thesampleswereimmersedintothepreparedSBFforpreparingHAPbiomaterialcoatingTheanalyses

4、ofmorphology，compositionandelementswereperformedbyscanningelectronmicroscopy(SEM)，Xraydiffraction(XRD)andenergydispersivespectrometer(EDS)Theattachmentrate，proliferationandALPof3T3一E1osteoblastcellsonsamplesurfaceswerete

5、stedThebiocompatibilityofthepreparedHAPbiomaterialcoatingwasalsoevaluatedbyanimalacuteandsubacutetoxicitytest，oralmucosatest，micronucleustestandbloodcompatibilitytest，respectivelyThemainresultsaredrawnasfollows：thecorros

6、ionofTialloyWaSoccurredinthreesimulatingbodyfluid，andthemostseriouscorrosionisinASTheHAPbiomaterialcoatingmadebyMAOhassinglecomponentwithrelativelyregularshapeandcompactstructureTheadhesionofHAPbiomaterialcoatingswashigh

7、erthanthatoftheuntreatedTialloyTestsofcellproliferationandALPshowthat3T3一E1osteoblastcellsonHAPbiomaterialcoatingissignificantlyhigherthanthatoftheuntreatedTialloyAnimalexperimentsindicatethat，forHAPbiomaterialcoatingmad

8、ebyMAOorIAH，thereisnoshorttermtoxicityoralmucosairritation，teratogenicityandcarcinogenicityexhibitingthegoodbloodcompatibilityAsaresult，thepreparedHAPbiomaterialgradientcoatingmadebyMA0orIAHtreatmentshowsgoodbiosecuritya