Changes in Serum B-type Natriuretic Peptides to Detect Cardiac Insufficiency-A Clinical Study (Research).pdf

1、Aim: To investigate the association between change inblood serum BNP and cardiac function in patients with cardiac surgery.Methods:A total of 20 cases were investigated since December 2012 till June 2013. Among these, 11

2、 male and 9 female with an average age of 43.9 years. Blood samples were collected on1st day, 24 hours after surgery, 7th and on 14th day post-operation. The samples were then sent for Electrogenerated Chemiluminescence

3、to determine BNP concentrations. Variance analysis performed to compare pre-and post-operative t test results.Results:20 patients with preoperative BNP concentrations of 1718.63 ± 170.93pg/ml, after rising sharply and pe

4、aked 24 hours after surgery (5465.21 ± 725.95pg/ml), compared with preoperative significant importance to the difference (P=0.003), 7 days after surgery falling (3059.17 ± 861.57pg/ml), compared with preoperative signifi

5、cant importance to the differences (P=0.015)；Returned to preoperative levels 14 days after surgery (1807.99 ± 103.21pg/ml), slightly below the level before the 30 days after surgery (1455.21 ± 104.23pg/ml). Preoperative

6、BNP concentrations in 20 patients, cardiac function in Grade II 253.17 ± 191.92pg/ml,Grade III1788.23 ± 1588.36pg/ml, Grade IV 2859.27 ± 2473.16pg/ml, different heart functional NYHA classification and BNP concentration

7、were positively correlated (r=0.69,P<0.05).Conclusion:1. in patients before cardiac surgery LVEF does not accurately reflect the State of cardiac function. 2. After heart surgery operation early BNP concentration raised,