芯片毛細管電泳信號的小波消噪.pdf

1、大連理工大學碩士學位論文芯片毛細管電泳信號的小波消噪姓名：黃俊煌申請學位級別：碩士專業(yè)：測試計量技術(shù)及儀器指導教師：閆衛(wèi)平20050312芯片毛細管電泳信號的小波消噪SignaldenoisingbywavelettransformformicrochipcapillaryelectrophoresisAbstractAsapromisingtypeofminiatorizedtotalanalysissystem(uTAS)，Inte

2、gratedcapillaryelectrophoresis(ICE)hasundergonearapidprogressinrecentyearsDuetoits11ighthroughout，lowsamplerequirement，ICEhasbewidelyrecognizedasapowerfultoolforchemicalanalysesHowever，whenthesystemoflaserinducedfluoresc

3、enceisusedtodosomeanalysis，somebackgroundnoisesaleintroducedintothesignalbecauseoftheinfluenceofinslnmaent，11i曲voltage，andsomeotherfactorsTherefore，toachievellighsensitivityandaccuracy，thedenoisingofcapillaryelectrophore

4、sissignalisnecessarybeforedataprocessingWavelettransform(WT)，emergingasanoveltechnique，hasbeenshowntobeveryusefulinmanyfieldsComparedwithwindowedfouriertransformWTadoptsamorecomfortablewindowingtechniquewithvariablysized

5、timeregions，WaveletsarefunctionsthatarebothlocalizedinthetimeandthefrequencydomainsBecauseofthisproperty，bothtimeandfrequencycharacteristiCSofthesignalarecapturedinWTTherefore，WavelettransformWasappliedtonoiseonremovalca

6、pillaryelectrophoresiselectropherogramsSeveraltypicalwaveletfunctions，includingDaubechies、CoifletsandSymmlets，wereevaluatedFourtypesofdeterminingthresholdmethods，Sqtwolog，Rigrsure，Heursure，Minimaxcombinedwimhardandsoftth

7、resholdmethodsarecomparedThedenoisingstudy013syntheticsignalsshowsthatwaveletfunctionDaubechies12withaleveldecompositionof5andthethresholdmethodofSqtwologhardprovidetheoptimumdenoisingstrategyUsingthisstrategythenoiseons

8、ignalsforcapillaryelectrophoresiscanberemovedadequatelyComparedⅥdtlltheFouriertransformdenoisingmethodwavelettransformisanefficientmethodfornoiseremovalwithabetterpreservationoftheshapeofpeaksKeyWords：CapillaryEctrophore