海藻酸鹽修飾的藥物載體的制備及應(yīng)用.pdf

1、中國科學(xué)技術(shù)大學(xué)碩士學(xué)位論文海藻酸鹽修飾的藥物載體的制備及應(yīng)用姓名：董麗娟申請學(xué)位級別：碩士專業(yè)：分析化學(xué)指導(dǎo)教師：金谷201105AbstractInganicmicronanoparticleshavebeenusedwidelyintheelectronicschemicalbiologicalpharmaceuticalotherfieldsbecauseofitsspecialstructureperfmance.Partic

2、ularlytheyhavedevelopedrapidlyasthedrugcarriers.Hollowinganicmicronanosphereshaveattractedgreatinterestbecauseoftheiruniquestructureofalargecavitywhichcanbeusedasthecarrierofmanyobjects.Inthisstudywehavechosentheinganics

3、ilicathemagicmaterialasourstudyobjecttosynthesizehollowspheres.Throughsurfacemodificationoftheseinganicmaterialswecanobtainaminefunctionalizedhollownanospheresthenlinkedwithalginatewhichisagoodbiocompatibilitythenaturalp

4、olysacidesynthesizednewstyledrugcarrier.Specificallyprimarystudiesinthethesisareincludedasfollowing:1.Asimpleeffectivemethodfsynthesizingsilicahollowspheresispresented.ThesynthesisutilizesCaCO3assphericaltemplatefthesili

5、cagrowthtetraethylthosilicate(TEOS)isaddedtothetemplateasaprecursfthesilicafmation.AfterCaCO3sphericalceswereremovedbyaddingdilutedhydrochlicacidhollowsilicasphereswithsmoothsurfaceunifmshellthicknesswereobtained.Aminefu

6、nctionalsilicahollowsphereswerepreparedviathehydrolysisofAPTMsthenalginatewasfirstlygraftedontothesurfaceofaminesilicathenthealginatecoatingwasimmobilizedbygellingCa2ionsalginatewhichallowsthefmationofalginatemodifiedhol

7、lowSiO2.Daunubicinasaprobingdrugwasloadedintothecarrierthemaximumpercentofenveloploadwere55.6%27.8%respectively.2.Unifmsizedmonodispersesinglecrystalmagitehollowsphereswithadiameterof200300nmwerepreparedbyaonesteptemplat

8、efreeapproach.FeCl36H2Owasdissolvedinethyleneglycol(EG)addedethylenediamine(EDA)ThemixturewassealedinaTeflonlinedstainlesssteelautoclavereactedat200Cf12h.aminefunctionalizedmagichollowsphereswerepreparedviathehydrolysiso

9、fAPTMsthenalginatewasgraftedontothesurfaceofaminemagicthenthealginatecoatingwasimmobilizedbygellingCa2ionsalginatewhichallowsthefmationofalginatemodifiedhollowFe3O4.Daunubicinasaprobingdrugwasloadedintothecarriernotables