人組織激肽釋放酶-8及基質(zhì)金屬蛋白-9在宮頸癌中的表達(dá)及臨床意義.pdf

1、青島大學(xué)碩士學(xué)位論文人組織激肽釋放酶8及基質(zhì)金屬蛋白9在宮頸癌中的表達(dá)及臨床意義姓名：劉雪梅申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：婦科科學(xué)指導(dǎo)教師：紀(jì)新強(qiáng)20080517TheExpressionofKallikrein8ProteinandMMP9proteinisAssociatewiththeCervicalCarcinomaObjectiveToexaminetheexpressionofthecervicalcarcinoma，andtoa

2、ssesstheeffectsofKLK8proteinandMMP9proteinincervicalcarcinomaMethodsTheexpressionofKLK8proteinwasexaminedbyImmunohistochemistyin67casesthatcomposedof11caseswithnormalcervicaltissues，13caseswithchroniccervicitistissuesand

3、43caseswithcervicalcarcinomatissuesResults1KLK8proteinwaslocatedincervicalepithelialplasmaThepositiveexpressionrateofKLK8proteinwas698％incervicalcarcinomatissues，154％inchroniccervicitistissuesand0incervicalnormaltissues，

4、功eexpressionrateofKLK8proteinwassignificantlyhigherincellsofcervicalcancer(698％)thanthoseinnormalcervicaltissues(0)(P005)2MMP9proteinwaslocatedincervicalepithelialplasmaThepositiveexpressionrateofMMP9proteinwas767％incerv

5、icalcarcinomatissues；30％inchroniccervicitistissuesand273％incervicalnormaltissuesTheexpressionrateofMMP9proteinwassignificantlyhigherincellsofcervicalcancer(767％)thanthoseinnormalcervicaltissues(273％)(P005)3Statisticalana

6、lysiswasdonetoshowapositivecorrelationbetweenKLK8proteinandMMP9proteinexpression(rs=0443，P001)ConclusionT11epositiveexpressionrateofKLK8proteinandMMP9proteinincellsofcervicalcancerwashigherthanthoseinnormalandchroniccerv

7、icitistissueshumanAndstatisticalanalysiswasdonetoshowapositivecorrelationbetweenKLK8andMMP9expressionKLK8proteinandMMP一9proteinplayanimportantroleininvasionandmetastasistogetherandparticiputeinthepathogenesisofcervicalca