Ki67、EGFR、HER-2在宮頸上皮內(nèi)瘤變和宮頸鱗癌中的表達及意義.pdf

1、山西醫(yī)科大學碩士學位論文Ki67、EGFR、HER2在宮頸上皮內(nèi)瘤變和宮頸鱗癌中的表達及意義姓名：魏芳申請學位級別：碩士專業(yè)：病理學與病理生理學指導教師：衛(wèi)建平20070508山西醫(yī)科大學琢士學位論文ExpressionandsignificanceofKi67，EGFRandHER2inthediagnosisofcervicalintraepithelialneoplasiaandcervicalcarcinomaABSTRACTo

2、bjective：ToinvestigatetheexpressionandbiologicalsignificanceofKi67，EGFRandHER一2incervicalintraepithelialneoplasia(CIN)andcervicalcarcinoma，providingtheoreticalbasisforearlydiagnosisandprognosisofthediseaseMethods：For82ca

3、sesofpatients，theimmunohistochemicalmethodWasusedtodetecttheexpressionofKi67，EGFRandHER一2，andthengiveananalysisoftheresultswithclinicalpathologicalvariablesResults：Of82cases，10casesofcervicitis。10casesofCINI，15casesofCIN

4、II，15casesofCINIIIand32casesofcervicalcarcinomatheimmunohistochemicalpositivestainingofKi67，EGFRandHer2werebrownordarkbrown。whichwe陀respectivelylocatedinnucleus，cellmembraneandcytoplasm，cellmembrane；thepositiverateofKi67

5、incervicitis，CINI，CINIIC【NⅡIandeervicalcarcinomawereasbelowas0，40％，933％，100％and100％：thepositiverateofEGFRincervicitis，CINI，CINII，CINIIIandcervicalcarcmomawereasbelowas10％，90％，60％，666％and156％；thepositiverateofHer2incervic

6、itis。CINI，CINII，C日NIIIandcervicalcareinomawereasbelowas0，40％，733％，100％and687％Byallappearance，forthesethreekindsofproteins，theexpressionsinCINandcervicalcarcinomaweresignificantlydifferentfromthoseincerviticitisAftercompa

7、risombetweentwoadjacentgroups，theexpressionsofKi67andHer2weresignificantlydifferentbetweencervicitis，CINIandCINll，CINIII，cervicalcancer；theexpressionsofEGFRshoweddifferencebetweentwoadjacentgroupsThereWasapositivecorrela

8、tionbetweenKi67orHer2andcervicallesions；anegativecorrelationwaspresentedbetweenEGFRandcervicallesionsInaddition，therewasapositivecorrelationbetweenHer2andthesizeoftumorclinicalstage，andlymphnodemetastasisincervicalcarein

9、omaConclusion：Ki67maybeavaluableindicatoroftheprognosisforCIN；EGFRcouldbeallindicatorofthegoodprognosisforcervicalcancerbuttheeffectofHer2wasoppositeKi67，EGFRandHER一2couldbeusedasmarkersforearlydiagnosisofCINandcervicalc

10、arcinomaItcouldbehelpfulforincreasingtheratioofearlierdiagnosisinthefieldsofcervicalcarcmomaandprovidingassistanceforjudgingprognosisandtreatmentKeywords：Cervicalintraepithelialneoplasia，Cervicalcarcinoma，Ki67，EGFR，HER一2