磁性鐵氧體納米顆粒及其相關(guān)結(jié)構(gòu)的調(diào)控制備.pdf

1、東南大學(xué)碩士學(xué)位論文磁性鐵氧體納米顆粒及其相關(guān)結(jié)構(gòu)的調(diào)控制備姓名：孫永康申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：生物醫(yī)學(xué)工程指導(dǎo)教師：顧寧張宇20040601受主蘭苧!壁絲壁墨堡墅鲞壁塾墨苧塑莖墮塑墮塑絲型量————————————一AbstractTheresearchbackgroundofthispaperisbasedonthepreparationofmagneticmaterialsfortumourtherapybymagneticflu

2、idhyperthermia(MFH)Thematerialsinthisapplicationarerequiredtobebiocompatible，ofwhichtheFe304、Fe203withlowbiotoxicityarerationalcandidatesAtthesametimetheheatingabilityoftheironoxidenanoparticlesisduetothesynthesisroutean

3、disdirectlyrelatedwiththeefficiencyofthetherapySoatunablesynthesisrouteofironoxidenanoparticlesisnecessaryFurtheraresearchofthetunablesynthesisandthedevelopmentofrelatedironoxidenanostructuresareofimportancetotheresearch

4、ofMFHtherapyFirstlyaerationbubblingoxidizafionofacidifiedFes04nanoparticlessuspensionpreparedwithcoprecipitationmethodat90oCisusedtosynthesisyFe203nanoparticles，whichnearlyhavethesameheatingabilitywiththeFe304onesAfterth

5、is，theeffectsofinitialexperimentalconditions，suchastheratioofFe3、Fe2，reactiontimeandreactionvolume，onthefinalproductsarestudiedTheresultsshowthatthesizeCallbetunedin14m一30mnSubsequentlytheheatingabilityoftheFe304nanopart

6、iclescanbealteredduetothesizedifferencesBasedontheseresultsstablewaterdispersedmagneticfluidisobtainedwitllglutamicacidmodifying17nmTFe203nanoparticlesandcanbeusedfortheMFHtumortherapySecondlypurifiedoleicacidisusedtomod

7、ifytheFe304nanoparticlesbycoprecipitationmethodandyFe203byaerationbubblingoxidizationmethodMagneticfluidofnonpolarorganicdispersantisobtmnedandthechelatingstructuresofoleicacidonironoxidesurfaceareconfirmedtobebidentatea

8、ndoleate—bridgebiodentateconfigurationsAtthesametime，ionicmagneticfluidispreparedbymodifying7nnlFe304nanoparticlesproducedbyreductioncoprecipitationmethodFe304@Si02core—shellnanostmcturesareobtainedbytheconventionalSt6be

9、rpolycondensationwithdilutesilicatesolutiontreatmentdirectlyinethan01FurthermorethethicknessofthesilicashellandthestabilityincreasewiththeamountofTEOSAsto18n／nFe304nanoparticles，magneticdipolechainsencapsulatedwithsilica