侵襲性垂體腺瘤中VEGF和bFGF的表達及相關性研究.pdf

1、山西醫(yī)科大學碩士學位論文侵襲性垂體腺瘤中VEGF和bFGF的表達及相關性研究姓名：張素勤申請學位級別：碩士專業(yè)：神經(jīng)外科學指導教師：劉躍亭20090515一一一一————————————————————————————————————一IIllIli醫(yī)科入學形。學他滄文ExpressioasandrelatedresearchofVEGFandbFGFinnvasivepituitaryadenomasinasivepitmtaryaa

2、enomasAbstractObjective：Tostudyexpressionsofvascularendothelialgrowthfactor(VEGF)andbasicfibroblastgrowthfactor(bFGF)ininvasiveandnon—invasivepituitaryadenomasandtheirrelevanceanddiscusstherelationshipofthemwiththeinvasi

3、vegrowthofpituitaryadenomaMethods：Pituitaryadenomatissuesamplesof55cases，ofwhich30caseswereinvasive，noninvasivetherewere25cases，theUSeofHEstainingwastoobservetheorganization，structureandarrangementofpituitaryadenomacells

4、，andexpressionsofVEGFandbFGFweredeterminedbyimmunohistochemicaltechniqueinthespecimensResults：@PathologicalfeaturesofHEstainingbetweeninvasiveandnoninvasivepituitaryadenomasarenoteasytodistinguishunderthelightmicroscopew

5、hichshowsthecellheteromorphism，largenuclearnucleolievident，thesignificantproliferationofmesenchymalcellandthehyperplasiaofthecapillary②ThepositiveexpressionratesofVEGFwere70％in30casesofinvasivepituitaryadenomasand36％in25

6、casesofnon—invasivepituitaryadenomas砰：636PO05)，butthereissignificantcorrelationbetweenthetumorsizeandexpressionsofVEGFandbFGF(1P0。嬲)Thebiggerthetumorsizeis，thehigherthedegreeofexpressionsis。@Thereisapositivecorrelationbe

7、tweenVEGFandbFGFexpressionsininvasivepituitaryadenomas(r=O508，P=0。004)。Conclusions：OverexpressionsofVEGFandbFGFandtheinvasivegrowthofthepituitaryadenomaarecloselyrelatedwithasynergisticeffectbetweenthetwo，andtheyCallrefl