基于有監(jiān)督奇異值分解和類隨機森林決策方法的腫瘤特征基因篩選研究.pdf

1、杭州電子科技大學碩士學位論文基于有監(jiān)督奇異值分解和類隨機森林決策方法的腫瘤特征基因篩選研究姓名：陳巖申請學位級別：碩士專業(yè)：信號與信息處理指導教師：厲力華韓斌20091201杭州電子科技大學碩士學位論文IIABSTRACTCancerisoneofthemostlethaldiseasesthreateninghumanhealth.Traditionalmedicineisfacingchallengesinmeetingthenee

2、dsofdiagnosistreatmentinpersonalmedicine.WiththeadvancesofDNAmicroarraytechnologyitbecomespossibletomonitthoussofgenesattheexpressionlevelacrossthegenome.Manybiomarkersionapproacheshavebeenproposedsatisfyingclassificatio

3、nresultsachieved.Amongthemsupervisedfeatureionmethodsbiomarkersmainlybasedonclassificationqualityfilteringmethodsdetectdifferentialexpressedgeneshowevermicroarraydataarenotiousfthecurseofdimensionitisdesirablethattheedge

4、nesetisbiologicallyrelevantconsequentlyrobusttothenoisehighlyadvantageoustobuildreliableclassificationmodels.Inthisstudyweproposeastrategythatidentifiesbiomarkersprimarilyintermsoftheirclinicaloutcomerelevancethenadjustt

5、hecidatebiomarkersbasedontheclassificationquality.TechnicallySupervisedSingularValueDecomposition(SSVD)aRomFestbasedmethodareusedtocrelategeneswithcancerdiagnosticoutcomesfinetunetheedgenesetintermsofclassificationaccura

6、cyrespectively.Theadvantagesarethatratherthanidentifyinggenesfromtensofthoussofcidateswithsofewsamplesgenesarestedintodifferentgroupswhicharedramaticallysmallinnumberarebiologicalfunctionrelevant.Meimptantlytherelationsh

7、ipofgenesclinicaloutcomesarevisualizedGenesareessentiallyidentifiedintermsoftheirrelevancewithclinicaldiagnosticoutcomes.TheRomFestmethodisthenproposedtostthepreedcidategene.Theapproachwasteston3broadlyusedpublicdatasets

8、.Graphicallytheidentifiedgenesetshowsaclearassociationwithclinicalcanceroutcomes.Comparativestudystatisticalanalysisshowstheproposedmethodscomparesfavablytotheothertwotypicalgeneionmethodsintermsofclassificationover4clas

9、sifiers.Meimptantlytheidentifiedgenesdemonstratecloserrelationshipwithclinicaloutcomesarelessvariablecomparativelyinvarianttotheexternalinfluences.Ontologystudyliteratureresearchshowsthatmanyoftheidentifiedgenesarealsofo