骨橋蛋白及膜型基質(zhì)金屬蛋白酶-1在尋常型銀屑病中的表達及其相關(guān)性的研究.pdf

1、華中科技大學碩士學位論文骨橋蛋白及膜型基質(zhì)金屬蛋白酶1在尋常型銀屑病中的表達及其相關(guān)性的研究姓名：孫兆軍申請學位級別：碩士專業(yè)：皮膚性病學指導教師：劉厚軍涂亞庭20090501華中科技大學碩士學位論文華中科技大學碩士學位論文ExpressionofOPNMT1MMPinPsiasisvulgarisItsImplicationExpressionofOPNMT1MMPinPsiasisvulgarisItsImplicationPost

2、graduateSunZhaojunTutLiuHoujunTuYatingAbstractObjectiveToinvestigatetheexpressionofosteopontin(OPN)membranetype1matrixmetalloproteinase(MT1MMP)therelationshipofOPNMT1MMPinpsiasisvulgaris.MethodsExpressionofOPNMT1MMPwasme

3、asuredbyimmunohistochemicalSPmethodin21patientswithPsiasisvulgaris16healthyindividuals；ThemRNAleveloftheOPNMT1MMPinpatientswithPsiasisvulgarishealthyindividualswasdetectedbyreversetranionpolymerasechainreaction(RTPCR).Re

4、sultsTheproteinofOPNMT1MMPwereexpressedrespectivelyin90.5%85.7%of21psiasisvulgarisspecimens16casesofnmalskinarepositiverateof62.5%.Therewasasignificantdifferencebetweenpsiaticlesionalnmalepidermisbyx2test(bothp0.05).Seve

5、nteencaseswerepositivefbothOPNproteinMT1MMPprotein2negativefeitherOPNproteinMT1MMPprotein.PositivecrelationbetweenexpressionofOPNMT1MMPinpsiasisvulgarislesionsPearson’srs=0.863p0.05.ConclusionOPNMT1MMPinpsiasisvulgarisin