過敏性紫癜急性期血漿可溶性細(xì)胞間粘附分子-1和血管內(nèi)皮生長因子水平的變化及意義探討.pdf

1、青島大學(xué)碩士學(xué)位論文過敏性紫癜急性期血漿可溶性細(xì)胞間粘附分子1和血管內(nèi)皮生長因子水平的變化及意義探討姓名：劉偉申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：兒科學(xué)指導(dǎo)教師：張秋業(yè)2003.3.30英文摘要THESTUDYoFTHESIGNIFICANCEOFPLASMASOUBLEINTERCELLULARADHE—SIONMOLECULE一1ANDVASCULARENDO—THELIALGROWTHFACTORINPATIENTSWITHHENOCH—SC

2、HOENLEINPURPURAABSTRACTobjectiveToinvestigatethechangesandclinicalsignificancesofsoubleintercellularadhesionmolecule1(siCAM一1)andvascularendothelialgrowthfactor(VEGF)inchildrenwithHenochSchoenleinpurpura(HSP)MethodsPlasm

3、asiCAM一1andVEGFweredetectedin38childrenwithHSPinacutephaseand16normalchildrenbyELISAThelevelsofplasmasICAM一1andVEGFindif—ferentclinicalcategoriesofHSPwerecomparedResults①PlasmasICAM1levelsinchildrenwithHSPinacutephase[(3

4、672土611)ng／m1]weresignificantlyhigherthanthoseinhealthycontrols[(2591士371)ng／mOO=657，P005)②PlasmaVEGFlevelsinchildrenwithHSPduringtheacutephase[(2027112618)pg／m1]weremarkedlyhigherthanthoseinhealthycontrols[(498612421)pg

5、／m1]，(t一4783，P005)；plasmaVEGFlevelsinpatientswithgastrointestinalsys—teminvolvementofacutephase[(28006士16149)pg／m1]weremarkedlyhigherthanthosewithoutgastrointestinalsysteminvolvement[(1528814643)pg／m1]0=279，P005)；③Plasma

6、slCAM一1levelsofacutephaseofHSPweresignificantlypositivecorrela—tedtoplasmaofVEGFlevels(r=0484，P001)ConclusionsPlasmasICAM一1andVEGFinacutephaseofHSPweresignificantlyin—creased，andtheywerepositivecorrelatedtoeachother，whic

7、hsuggestthatsICAM一1andVEGFmayplayacrucialroleinpathogenesisofHSPsiCAM一1mayhaveanimportanteffetonchangesofnephritisofHSP。meanwhileVEGFmayhaveacloserealationshipwithgastrointestinalsysteminvolvementofHSPKEYWORDS：purpura，Sc