26560.酵母基因組序列分析

1、河北工業(yè)大學碩士學位論文酵母基因組序列分析姓名：于娜申請學位級別：碩士專業(yè)：生物物理學指導教師：賈孟文20100501?????????iiSequenceAnalysisofYeastGenomeABSTRACTThemainobjectiveof“HumanGenomeProject“istodeterminethefullhumangenomesequencethenclarifythegenelocationstructuref

2、unctionregulateoftheexpressionthepathogenesisofmajdiseases.Withthesequencingofhumangenomesequencecompletionitwasrecognizedthatcrackedthehumangenomebasesequencedoesnotmeanthatalreadyknowthesecretoflife.Modelganisms(egSaco

3、mycescerevisiae)hasasimplestructuregeiccompositionofsmalllessfeaturessothatmodelganismsgenomeresearchismeeasily.Therefethelevelofthegenomeofyeastgenomefhumangenomeresearchtoprovidepositiveguidance.Thisthesisincludesfourp

4、arts:PartI:AbriefintroductiongenomeofSacomycescerevisiaeitsdevelopment.PartII:Introductionassociatedwiththisthesisbiologystatistics.PartIII:BasedontheSacomycescerevisiaegenomesequencedatageneexpressiondatageneencodingthe

5、proteinclassificationdatatheestablishmentofadatabasefstatisticalanalysis.PartIV:Intheyeastgenomelevelthestatisticalanalysisofthedifferentgrowthstagesinthecelltherelationshipbetweengenefunctiongeneexpressionleveltherelati

6、onshipinfunctionofgenesinthegeneexpressionlevelscodonbiasGCcontentgenelength.Theresultsshowedthat:inthedifferentstagesofmitosistheexpressionlevelsofdifferentgenesatdifferentofclassificationwiththeperiodofbiologicalproces

7、sesrelatedtogeneclassesthantheotherfunctionalclassesarespecificexpression.Inthewholegenomeexpressionsequenceacteristicparameterswassignificantlycrelated.Howeverfoundinthecrelationanalysisbetweentheexpressionofdifferentfu

8、nctionalclasssequenceacteristicparametersthatallfunctionalclassificationwiththeCAICBIweresignificantlycrelatedthecrelationcoefficienthigherthanthewholegenome.HowevernotallfunctionalclassesGCcontentgenelengthwassignifican