朱武洋-中國疾病預防控制中心

1、<p><b>　　朱武洋</b></p><p><b>　　一、個人簡介</b></p><p>　　朱武洋，男，博士，研究員，碩士生導師。疾病預防控制國家重點實驗室（SKLID）獨立PI，病毒病所倫理委員會委員。主要從事狂犬病預防控制相關(guān)的應(yīng)用基礎(chǔ)和基礎(chǔ)研究，作為第一作者或通訊作者在SCI期刊發(fā)表論文二十余篇。榮獲三項省部級成果，

2、包括省部級一等獎一項，省部級二等獎二項。作為主持人或分課題主持人先后承擔國家自然基金、國家科技重大專項、SKLID等總共十余項國家級課題。</p><p><b>　　二、主要研究方向</b></p><p>　　1. 狂犬病病毒、黃病毒及甲病毒反向遺傳學研究；</p><p>　　2. 狂犬病病毒轉(zhuǎn)錄及復制相關(guān)的分子機制研究。</p&g

3、t;<p><b>　　三、代表性科研項目</b></p><p>　　1、硫酸肝素受體介導的病毒感染作用機理研究、國家自然科學基金（30970160）；</p><p>　　2、云南省狂犬病毒糖蛋白基因分析及抗原性研究、國家自然科學基金（81160353）；</p><p>　　3、基于化學基因組學的病原診治生物標志物高通量篩選

4、平臺、國家科技重大專項（2013ZX10004-601-01）；</p><p>　　4、重大傳染病應(yīng)急處置檢測技術(shù)平臺、國家科技重大專項（2013ZX1004-101）；</p><p>　　5、新型RNA病毒載體研制平臺技術(shù)與應(yīng)用研究、國家科技重大專項（2009ZX1004-705）；</p><p>　　6、基因組3’末端保守序列在乙腦病毒復制中作用的研究、國

5、家重點實驗室（2011SKLID205）</p><p>　　四、代表性論文、成果（2011年以來）</p><p>　　Hang Zhou, Wuyang Zhu (Co-first author), Jianfeng He, Yu Li, Hongjie Yu*；Probable Rabies Virus Transmission through Organ Transplantati

6、on, China, 2015; Emerging Infectious Diseases, 2016, 22 (8): Ahead of Print.</p><p>　　Wuyang Zhu*, Xiaoyan Tao, Pengcheng Yu, Shuqing Liu, Zhuozhuang Lu; Enhancement of Virus Replication in An Influenza A Vi

7、rus NS1-Expresssing 293 Cell Line, Biomedical and Environmental Sciences, 2016, 9(3): 224-228.</p><p>　　Wuyang Zhu, Lingling Deng, Yan Weia, Huanqin Wang, Jinglin Wang, Guodong Liang; A substitution in nsP1

8、combined with a double substitution in E2 glycoprotein renders Sindbis-like virus XJ-160 fully neurovirulent for adult mice; Virus Research; 2015, 96: 1-4.</p><p>　　Xiao-Yan Tao, Zhen-Yang Guo, Hao Li, Wen-T

9、ao Jiao, Xin-Xin Shen, Wu-Yang Zhu, Simon Rayner, Qing Tang; Rabies Cases in the West of China Have Two Distinct Origins; PLoS Neglected Tropical Diseases; 2015, 9(10): e0004140.</p><p>　　Jinglin Wang, Huach

10、un Li, Yuwen He, Yang Zhou, Jingxing Meng, Wuyang Zhu, Hongyu Chen, Defang Liao, Yunping Man; Isolation and Genetic haracterization of Mangshi Virus: A Newly Discovered Seadornavirus of the Reoviridae Family Found in Yun

11、nan Province, China; PLoS ONE, 2015, 10: (12): e0143601.</p><p>　　Xiaoyan Gao, Xiaolong Li, Minghua, Shihong Fu, Huanyu Wang, Zhi Lu, Yuxi Cao,Ying He, Wuyang Zhu,Tingting Zhang, Ernest A. Gould, Guodong Lia

12、ng; Vaccine Strategies for the Control and Prevention of Japanese Encephalitis in Mainland China,1951–2011; PLoS Neglect Trop Dis; 2014,8(8): e3015.</p><p>　　Wuyang Zhu*, Juanjuan Fu, Yan Wei, Huanqin Wang,

13、Guodong Liang*；Induction of humoral and cellular immune responses against hepatitis C virus by vaccination with replicon particles derived from Sindbis-like virus XJ-160; Archives of Virology, 2013, 158:1013–1019.</p&

14、gt;<p>　　Zhu Wuyang, Jiangjiao Li, Huanqin Wang, Ying He, Guodong Liang?; Development of EGFP/GLUC-tagged Sindbis-like virus XJ-160, Journal of Virological Methods, 2013, 89:235-237.</p><p>　　Wang Jin

15、glin, Zhu Wuyang*, Shihong Fu, Li Wenjuan, Zhang Hailin, Guodong Liang*; Phenotypic and molecular characteristics of plaque-purified MX10 virus, an Oriental-Australian genotype of Sindbis virus from Yunnan, China, Archiv

16、es of Virology, 2013, 158:71–75.</p><p>　　Wuyang Zhu, Ting Zhao, Guodong Liang*; Specific nucleotide changes in the subgenomic promoter region influence infectivity of the Sindbis virus, Intervirology, 2013,

17、 56:337–342.</p><p>　　Jiangjiao Li, Wuyang Zhu (Co-first author), Huanqin Wang, Jiandong Li, Quanfu Zhang, Ying He, Jia Li, Juanjuan Fu, Dexin Li, Guodong Liang*; Rapid, Specific Detection of Alphaviruses fr

18、om Tissue Cultures Using a Replicon-Defective Reporter Gene Assay, PLoS ONE, 2012, 7(3): e33007.</p><p>　　Zhu Wuyang, Guodong Liang*; Current Status of Canine Rabies in China、Biomedical Environmental Science

19、s, 2012, 25(5): 602-605.</p><p>　　Wuyang Zhu, Jiangjiao Li, Li Tang, Huanqin Wang, Jia Li, Juanjuan Fu, Guodong Liang*; Glycoprotein is enough for sindbis virus-derived DNA vector to express eterogenous gene

20、s, Virology Journal, 2011, 8:344.</p><p>　　Zhu Wuyang, Guodong Liang*; How does Cellular Heparan Sulfate Function in Viral Pathogenicity? Biomedical Environmental Sciences, 2011, 24(1): 81-87.</p><