1，3-二芐基四氫呋喃并[3，4-d]咪唑-2，4-二酮的合理利用研究和(R)-4-甲基-γ-丁酸內(nèi)酯在S-構(gòu)型Citralis Nitrile合成中的應(yīng)用.pdf

1、上海師范大學(xué)碩士學(xué)位論文1，3二芐基四氫呋喃并[3，4d]咪唑2，4二酮的合理利用研究和（R）4甲基γ丁酸內(nèi)酯在S構(gòu)型CitralisNitrile合成中的應(yīng)用姓名：李清申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：田偉生金榮華20100501AbstractWiththedevelopmentofhumansocietysomeproblemriseup，suchaslacknessofresources，environmentalpol

2、lutionetcHowtoenhancetheutilizationandreducewasteofresourcesbecameoneoftheimportanttasksforchemicalresearchersTherationalutilizationofresourcecompoundsisoneofthemaintasksofOUgresearchgroupBasedontheresearchofrationalutil

3、izationoftheabundantsteroidalsapogenins，Mymasterdissertationworkmainlyfocusedonhowtouse1，3一Dibenzyltetrahydro一1Hfuro[3，4一d]imidazole一2，4dioneandTigogenin，myworkconcernedonthefollowingsections1Inthispaper1，3Dibenzyltetrah

4、ydro一1H—furo[3，4d】Imidazole一2，4dioneWasoxidizedbyNaCl0to1，3Dibenzyl一4，5cidicarboxylicAcid2Imidazolidonewiththeyieldof590％，itisthebasicrawmaterialofsynthesizingvitaminHThemethodisverysimple，easytooperateandenvironmentalIt

5、alsohasveryhighindustrialproductionvalue，andwetrytouse1，3Dibenzyltetrahydro一1Hfuro[3，4d]imidazole2，4dioneforthesynthesisofdiamineligands2Toobtainthe(R)4methyl—dihydrofuran一2(3H)onefromtheTigogenin’Soxidativedrgradationby

6、reseachingonthedrgradation’Scostoffthenconverteditbythesereactionsofthebenzyl—openinglithiumaluminumhydrogenreductionhydroxylsiliconprotection，raneyNickelDebenzylation，hydroxylbromide，changingthebromidetophosphonium，then

7、reactionwithbenzaldehydetothekeyintermediatesof(S)CitralisNitrilebythesixstepsreactionswiththeoverallyieldof380％Keywords：1，3Dibenzyltetrahydro1Hfuro[3，4一d]imidazole一2，4dione，resourcechemistryTigogenin，(R)一4一methyldihydro