咪唑啉和二肽類催化劑的設(shè)計合成及應(yīng)用研究.pdf

1、西南大學(xué)碩士學(xué)位論文咪唑啉和二肽類催化劑的設(shè)計合成及應(yīng)用研究姓名：陳復(fù)彬申請學(xué)位級別：碩士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：彭云貴20070401兩南大學(xué)碩f。學(xué)位論文TheStudyontheSynthesisandApplicationofChiralDipeptideandImidazolineSpecialty：OrgChemResearch：OrgSmallmolecularCamTutor：ProfYunGuiPengAuthor：F

2、uBinChenAbstractInthisdissertationwehavedesignedandsynthesizedtheimidazolinepbenol，pyrrolidiIleimidazolineanddipoptidewhichcomposedtheprolinethreekindsofbifunctionalcatalystsandappliedthemtocatalyzeasymmetricreactionsPre

3、liminarystudyindieatedthattheimidazoline—phenolcatalystwith10WreactivitvandthepyrrolidineimidazolinecatalystwithgoodreactivityintheAldolandMichaelreactioninordertogetgoodresultsWChavealSOoptimizedthesolventadditiveandfou

4、ndthatthereactivitywoddbeenhancedbyaddingTFAInthesametime，wealSOfoundthattheAIdolproductswereobtainedwithhighreactivityandSeleetivitycatalyzedbythedipe口tidewhichderivedfromprolineWbhavestudiedtheinfluenceofelectroniceffe

5、ctandsteIiceffect011thereactionbyvariedthestructureofanotheraminoacidandterminalamideofthedipeptideandfoundthatthebestcatalystwas489anduseitinthedirectasymmetricAldolreationnereactiontemperaturessolventsandadditivesweres

6、creenedandfoundthatthepropertemperaturewas20℃仕∞bestsolventWaSCHChandtheadditivewasAcOHor2MePhCOOHWiththeoptimalconditionsinhandweinvestigatedthereactionofcyclohexanonewithvariousaldehydes，highisolatedyields(upto99％)anden