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1、在醫(yī)學(xué)上，當(dāng)出現(xiàn)一種新的醫(yī)療方法和藥物時(shí)，為了證明新方法的效用通常都要將新方法和現(xiàn)有方法進(jìn)行比較。這種比較通常用等價(jià)性和非劣性?xún)蓚€(gè)指標(biāo)進(jìn)行判定。
本文研究的是2×2配對(duì)試驗(yàn)數(shù)據(jù)的非劣行檢驗(yàn)問(wèn)題。本文先引入了在漸進(jìn)正態(tài)分布下的具約束條件Fieller型的極大似然估計(jì)估計(jì)方法。本文則重新定義了統(tǒng)計(jì)量，用極大似然估計(jì)的方法去估計(jì)參數(shù)，并在配對(duì)表中數(shù)據(jù)服從四項(xiàng)分布的基礎(chǔ)上進(jìn)行非劣性檢驗(yàn)。本文得出了檢驗(yàn)功效和計(jì)算樣本量的函數(shù)。我們的
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