microdoseflareregimen(1)-thewomen'sclinic

1、Ovarian Stimulation for IVF Procedures,Dr Milton Leong梁家康醫(yī)生,微劑量Flare法(1),口服避孕藥皮下注射20mcg 亮丙瑞林 （一天兩次）X2天應(yīng)用uFSH 以刺激卵巢結(jié)果:? 卵母細(xì)胞FSH使用量少Source: Scott et al, 1994,微劑量Flare法(2),口服避孕藥皮下注射40mcg 亮丙瑞林 （一天兩次）肌注4 IU/d 生長(zhǎng)激素

2、使用uFSH 2 天后監(jiān)測(cè)結(jié)果:? 取消率? E2 濃度, 卵母細(xì)胞數(shù)目Source: Schoolcraft et al, 1997,微劑量Flare法(3),口服避孕藥皮下注射40mcg 亮丙瑞林 （一天兩次）2天后開始應(yīng)用uFSH結(jié)果:? 取消率? E2, 卵母細(xì)胞數(shù)目Source: Surrey et al, 1998,延長(zhǎng)停藥時(shí)間 (1),目的: 避免過度刺激臨床: 直至 E2 ?

3、3000 pg/mL停藥,延長(zhǎng)停藥時(shí)間(2),Sher, 1995當(dāng)30% 卵泡 > 15mm開始Nilsson, 1999當(dāng)3 個(gè)卵泡 > 17mm開始,Mean SE ? E2 and LH conc. Before and during the coasting period in superovluation cycles,Characteristics of representative IVF-ET c

4、ycles in which coasting was used,,General Principles of combined pituitary suppression / ovarian stimulation therapy (From Insler and Lunenfeld),Crude pregnancy rates using different GnRH agonist protocols in IVF (From

5、Daya),,The structure of GnRH agonistic analogues,Outcome results according to type of protocol and gonadotrophin used (n=13426),,Oocyte damage, pronuclear status and embryo cleavage after ICSI,Trade names, plasma half-l

6、ives, relate potency, route of administration and recommended dose for the clinically available gonadotrophins,Proposed protocols for poor responders,Characteristics of IVF-ET cycles in which follicular maturity was atta

7、ined before (gp 2A) or after (gp 2B) the coasting period,Gonadotropin and ovarian steroid hormone levels with microdose flare regimen: gonadotropin treatment day 1 vs day 6,Comparison of conventional IVF and ICSI proced

8、ure on sibling oocytes of 50 patients with tubal infertility,Outcome of embryo transfers after ICSI,Schematic representation of different protocols using GnRH agonists in combination with gonadotrophins for ovarian stimu