結(jié)核病潛伏期

1、流式網(wǎng)絡(luò)課堂第五課,流式新聞,蘇州躍亞技術(shù)部 孟琳 2011-11-30,利用CD4+TNF-a+細(xì)胞群體鑒別結(jié)核病的潛伏期和活動期,,,,,,,,latent Mtb infection,active tuberculosis disease,The frequency of single-positive TNF-α–producing CD4+ T cells was higher in in

2、dividuals with active disease,,the cutoff of 37.4% of single-positive TNF-α,,,,,結(jié)論： The proportion of TNF-α single-positive Mtb-specific CD4+ T cells, and particularly the cutoff at 37.4%, could discriminate be

3、tween latent infection and active disease. The sensitivity and specificity of the flow cytometry–based assay were 67% and 92%, respectively, the positive predictive value was 80% and the negative predictive v

4、alue was 92.4%. The proportion of single-positive TNF-a Mtb-specific CD4+ T cells is a new tool for the rapid diagnosis of active tuberculosis disease.,Th17細(xì)胞在乳腺癌組織中的表達(dá)及與臨床參數(shù)的關(guān)系,We observed that express

5、ion of Th17 cells was signficantly higher in breastcancer compared to normal breast tissue.,,,A :In cancer tissue.,B: In normal tissue,In cancer tissue, expressions of IL-17, IL-1b, and IL-6 positively correlated with e

6、xpression of Th17 ; Expression ofTh17 was not associated with expression of Treg.,Th17細(xì)胞數(shù)與腫瘤臨床分期，血管浸潤和淋巴結(jié)轉(zhuǎn)移數(shù)呈負(fù)相關(guān),結(jié)論： Th17細(xì)胞參與抗腫瘤免疫應(yīng)答，并且可能成為未來免疫治療預(yù)后的檢測指標(biāo)。,腫瘤抑制基因RUNX3在骨髓巨細(xì)胞瘤中的作用,GCTB病人體內(nèi)RUNX3的表達(dá)率明顯低于正常骨髓組織,上圖為RU

7、NX3 mRNA在正常人（N）和腫瘤患者（C）中的水平,下圖為RUNX3蛋白的表達(dá)。,體外表達(dá)的RUNX3強(qiáng)烈抑制GCTB細(xì)胞的生長，誘導(dǎo)細(xì)胞凋亡,結(jié)論： 1 本文首次確定RUNX3在GCTB中作為抑制基因。 2 RUNX3的作用提高了GCTB的診斷和治療。 3 在GCTB 中RUNX3 的信號通路仍不是很清楚，需要進(jìn)一步研究。,UCMD（先天性肌營養(yǎng)不良癥）組,未破膜處理,破膜處理,對照組,BM（貝特

8、倫肌?。┙M,Ⅵ型膠原蛋白在成纖維細(xì)胞中的表達(dá)（細(xì)胞膜p < 0.001和胞漿內(nèi)）,（19.6 ± 10.0）%,（65.3 ±10.7）%,,（54.1 ± 8.0）%,,Ⅵ型膠原蛋白在胞漿內(nèi)表達(dá)量（p < 0.001)）,30 ± 10.3%,70.9 ± 7.5%,42.0 ± 8.5%,結(jié)論 ： 和對照組相比，在UC