透皮吸收貼劑,透皮給藥系統(tǒng)2016

1、,透皮遞藥系統(tǒng)Transdermal Drug Delivery System(TDDS),,,,,經(jīng)皮給藥系統(tǒng)（ transdermal drug delivery system, TDDS ）是指經(jīng)皮膚敷貼方式給藥，應(yīng)用藥劑學(xué)、物理學(xué)或化學(xué)方法及手段，促進(jìn)藥物穿過皮膚，由毛細(xì)血管吸收進(jìn)入體循環(huán)并達(dá)到有效血藥濃度，實(shí)現(xiàn)疾病治療或預(yù)防的給藥技術(shù)。,,經(jīng)皮給藥系統(tǒng)TDDS,常用的劑型為貼劑(patch)，還有軟膏劑、硬膏劑、涂劑和氣霧劑

2、等,國際上：東莨菪堿、硝酸甘油、雌二醇、芬太尼、煙堿、可樂定、 睪酮、硝酸異山梨酯、左炔諾酮等,國內(nèi) ：東莨菪堿、硝酸甘油、雌二醇、芬太尼、可樂定等,,目前上市的藥物,皮膚自外向內(nèi)分為表皮、真皮和皮下組織三部分,藥物通過皮膚的途徑,1 Transdermal delivery of clonidine,Figure 1. Schematic of transdermal patch system

3、 of clonidine.,妥瑞綜合癥,阿片類藥物戒毒,Figure 2. Schematic of future transdermal patch system.,Figure 3. Schematic of modified PermeGear In-Line diffusion cell for transdermal flux analysis,Figure 4. A representative permeation

4、profile of clonidine through CNT membrane and skin after application of different bias sequences.,2 Transdermal delivery of siRNA,皮膚病,(A) The size of the microneedle array patch,(B) Configuration of the microneedle arr

5、ay patch and (C) Structure of a single microneedle model.,Delivery of siRNA strongly inhibits targeted Gapdh gene expression. *P < 0.05, t test.,TDDS Work on the whole body,What is Rotigotine（羅替戈汀）,多巴胺受體激動劑早期或晚期帕金

6、森羅替戈汀透皮系貼劑/Neupro,多巴胺 羅替戈汀,NEUPRO,第一個被允許上市的治療帕金森的透皮貼劑（2007）Neupro貼劑采用硅酮作為基質(zhì)治療不寧腿綜合癥（2008）,European Journal of Pharmaceutics and Biopharmaceutics, Volume 88, Issue 3, November 2014, Pages 586-593,NEUPRO,