卵巢上皮性腫瘤中凋亡相關(guān)蛋白Fas、FasL、BCl-2、P53表達(dá)及意義的研究.pdf

1、蘇州大學(xué)碩士學(xué)位論文卵巢上皮性腫瘤中凋亡相關(guān)蛋白Fas、FasL、BCl2、P53表達(dá)及意義的研究姓名：李青申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：腫瘤病理指導(dǎo)教師：吳德明陳同鈺2001.10.1塑墨f：墮絲壁墮!型立塑差曼魚￡型：!!些：堡蘭!：!：￡型墨墮絲重墨型!鑒一——————蘭堡!竺生AbstractPurposeToinvestigatetheexpressionofapoptosis—relatedproteins，F(xiàn)as、Fasliga

2、nd(L)、BC1—2、P53inhumanOvarianepithelialneoplasmsandtOexplorethesignificantintumorigenesisMethodsImmunohistochemistrystainingwasusedtocheckthepresenceandthefeaturesofFas、FasL、BC1—2andPssproteins，materialofinvestigationinc

3、luded10casesofadenoma，10withlowpotentialmalignancy(LPM)and39withcarcinomaResultsThepositiverateofBC1—2expressionwere700％inadenoma，400％inLPMand231％incarcinoma，(P=003)inverseofP53expression，cellsexpressingP53increasedinbor

4、derlinetumorsandmoreincancer(P2002)，F(xiàn)asandFasLwerehighlyexpressedinalltumors，F(xiàn)asexpressionwasnodifferenceineachcategory(P=O88)，F(xiàn)asLwasstatisticallysignificant(P=003)LevelsofP53andFasLproteinexpressionwithadvancedCancerGI

5、GOstagesIIIandIV)exceededthosewithlocalizedCancer(FIGOstagesIandII)(P=005andP=001)ConclusionsTheinitialdevelopmentofovarianepithelialneoplasmswasconcisionofexpressionofapoptosis—relatedproteins，BC1—2、P53、Fas、andFasLIncar