大肝癌中整合素αv亞基、基質金屬蛋白酶2表達及微血管計數的研究.pdf

1、中南大學碩士學位論文大肝癌中整合素αv亞基、基質金屬蛋白酶2表達及微血管計數的研究姓名：劉合利申請學位級別：碩士專業(yè)：外科學（普外）指導教師：楊連粵2001.5.1!塑查蘭堡主蘭堡笙奎MVDandtheExpressionofIntegrinⅡvSubunit、’MMP2inLargeHepatocellularCarcinomaAbstractobjective：Toinvestigatethepathologicalcharacte

2、risticsandmolecularitemsrelativetoinvasionandmetastasisofsolitarylargeHCCToexplorethebiologicalcharacteristicsofsolitarylargeHCCMethods：43pathologicallyconftrmedHCCspecimensobtainedfrompatientswithHCCresectedingeneralsur

3、gerydepartment，XiangYahospital23HCCspecimenscontainedpericarcinomatouslivertissue(PCLTlcmawayfromthecarcinoma)TheHCCspecimensweredividedinto3groupsaccordingtodiameterandthenumberofnodes：solitarylargeHCC(SLHCC，diameter5cm

4、)20cases，smallHCC(SHCC，diameter一一2，excepttwonodesHCCwiththetotaldiameter一5cm)10casesTilepathologicalcharacteristicsamongthethreegroupsofHCCswerecomparedMVDandtheexpressionofintegrinovsubunit，MMP一2amongthethreegroupsofHCC

5、sweredetectedbyimmunohistochemistricalmethodResulls：1CizrhosisandcelldifferentiationofSLHCCwerebetterthanthoseofMNHCC(P005)ThetumornecrosiswasmoreobviousinSLHCCthaninSHCC(P005)2PositiverateofintegrinavsubunitinSLHCCcance

6、rcellswas45％，while80％inMNHCCcancercellsPositiverateofMMI2inSLHCCcancercellswas70％while100％inMNHCCcancercellsPositiverateofMMP一2inSLHCCstromalcellswas20％，while70％inMNHCCstromalcellsMVDwas1256512inSLHCCwhile1676503inMNHCCM