tPA、PAI-1活性與自然流產的相關性及自然流產病因的多因素分析.pdf

1、中南大學碩士學位論文tPA、PAI1活性與自然流產的相關性及自然流產病因的多因素分析姓名：丁虹申請學位級別：碩士專業(yè)：產科高危妊娠指導教師：朱付凡20040501中南大學碩士學位論文英文摘要ABSTRACTTherelativitybetweentPA，PAl一1activityandspontaneousabortion，andthemultiplefactoranalysisabouttheetiologyofspontaneous

2、abortionobjectiveTostudytherelativitybetweenthetissuetypeplasminogenactivator(tPA)activityplasminogenactivatorinhibitortype1(PAj1)activityandspontaneousabortionandthemultiplefactoranalysisabouttheetiologyofspontaneousabo

3、rtionaswellastheaffectontPAandPAl一1activitythatcausedbyanticardiolipinantibodiesMethodsCandidateswerecomefromtheSecondXiangyaHospitalofCentralSouthUnivelsityincludethepregnantornonpregnantwomenwithandwithoutthehistoryofs

4、pontaneousabortionChromogenicassaywereusedtodetecttPAactivityandPAl一1activityinplasrrLSerumantibodiestocardiolipin(CL)weremeasuredbyaspecificenzymelinkedimmunosorbentassayLogisticregressionanalysiswasperformedtodetermine

5、therelativeriskfactorsfortheetiologyofspontaneousabortionResultsThetPAactivityincreasedlinearlyduringpregnancyTllePAl一1activitydecreasedlinearlyduringearlyandrniddlepregxmncyandincreasedalter32weeksneplasmtPAactivityofth

6、ewomenwiththehistoryofspontaneousabortionarestatisticallysignificantlowerthanconlrolsamongearlypregnantandnonpregnantwomenneriskfactorsofspontaneousabortionfrommultivariateanalysiswerethepositiveaCLandthedecreaseoftPAact

7、ivitynlet_PAactivityhasnotdifferencebetweenwomenwithaCLpositiveandnegativenePAllactivityWasstatisticallyhigheramongpregnantwoInenwithpositiveaCLthannegativeConclusionTbeincreasedtPAactivityanddecreasedPAI1activityareimpo