MMP-2和TIMP-2在胃癌組織中的表達及預后（生存時間的關系）研究.pdf

1、佳木斯大學碩士學位論文MMP2和TIMP2在胃癌組織中的表達及預后（生存時間的關系）研究姓名：劉惠濤申請學位級別：碩士專業(yè)：病理學與病理生理學指導教師：孟丹20080410——一絲塑墮蘭堡絲咝絲AbstractObjective：ToinvestigatetherelationshipbetweenexpressionofMMP2andTIMP2withinvasion，metastasisandprognosisofpatientsw

2、ithgastriccancerMethods：Sixtyeightsampleswereobtainedfromgastrectomyspeimensfrompatientswithgastriccancerwhohadundergonegastrectomyfor68gastriccancerSPimmunohistologicalstainingWasusedtodetecttheexpressionofMMP2andTIMP2i

3、nsixty—eightcasewithgastriccancertissuesResults：ThepositiveexpressionofMMP2andTIMP2wasmostlyshowedincytoplasmicstainingofcancerouscells，andpositivecellswerescattered，fragmentaryorformapileAfewfibroblaststainedwereobserve

4、dTherateofpositiveimmunoreactivityforMMP2andTIMP2was524％(33／63)and54％(34／63)ThemorehighexpressionofMMP2ingastriccancerthemoredeeplystainingofhistologicdifferentiation(P001)；TheexpressionofMMP一2inpatientswithearlygastricc

5、ancerislowerthanthatwithadvancedgastriccancerTheexpressionofMMP2inpatientswithgooddifferentiatedtypeislowerthanthatwithundifferentiatedtypeTheexpressionofTIMP1inearlygastriccarcinomahasstronglyexpressedbutweaklyexpressed

6、inadvancedgastriccarcinomaTheexpressionbetweenTIMP2andMMP2ingastriccancerwasnegativecorrelated(P0OO1)TheexpressionofMMP2ingastriccanceroustissuesWascorrelatedwithintissuesoflymphnodesmetastasis，butmeexpressionofTIMP2WaSo

7、fnorelationConclusion：TheexpressionofMMP2andTIMP2ingastriccarcinomahadextensiveheterogeneity，thepositiveexpressionofbothwasmostlyshowedincytoplasmstainedofcancercell，andthatpositivecellswerescattlered、fragmentaryorformap

8、ileAfewfibroblaststainedwereobservedTheexpressionofTIMP2waswellOnintestinemetaplasiaandhyperplasiainpericancerouscells，butnoexpressionofMMP2WasobservedTheexpressionofMMP一2werecloselycorrelatedwithhistologicdifferentiatio

9、npathologicstageandlymphnodemetastasis(PoO1)，theexpressionofTIMP2wascloselycorrelatedwithhistologicclassificationandpathologicstageaswell(Po05)；TheexpressionofMMP2Wascorrelatedwithsurvivaltime(PO05)，butthethatofTIMP2Waso