豚鼠透鏡誘導(dǎo)性近視及哌侖西平對其的作用.pdf

1、復(fù)旦大學(xué)碩士學(xué)位論文豚鼠透鏡誘導(dǎo)性近視及哌侖西平對其的作用姓名：歐陽朝祜申請學(xué)位級別：碩士專業(yè)：眼科學(xué)指導(dǎo)教師：褚仁遠(yuǎn)2001.4.25LeasinducedMyopiainGuineaPigsandEffectsofPirenzepine011theMyopiaAbstractPurposeTostudytheeffectsofconcavelensesoneyegrowthandrefractivedevelopmentanddis

2、cussthemechanismsoflens。inducedmyopia，guineapigswereusedassubjectiveInaddition，theeffectsoftopicalpirenzepineO／1themyopiawerestudied，anditsmechanismsandfeasibleperspectiveofclinicalapplicationofthedrugwerediscussedMethod

3、sFourweekoldguineapigs(n=32)wererandomlydividedintosixgroupsGroup1wasusedasnormalcon901withoutanytreatmentNegativesphericlensesof5Dand—20DwerefittedtounilateraleyesinGroupIIandIV，一10DinGroupIII、VandVI，allwithcontralatera

4、leyesasuntreatedcontr0110％pirenzepineeyedropsweretopicallyadministeredtotreatedlateralofGroupⅥwhile024％NaClsolutionwasusedincontroleyesofGroupVIandbilateraleyesofGroupV1ldayslaterlenseswereremovedanddrugapplicationwasdis

5、continuedAnalyzingthedifferencebetweenthechangesofrefractionandaxiallengthofbotheyesassessedtheeffectsoflensinductionanddrugAfterenucleation，8eyesof4animalsrandomlychosenwereprocessedformeasuringscleralthicknessand16eyes

6、chosenfromGroupVandV1werehistologicallyexaminedforpossibletoxicityofpirenzepineResultsAfter11daysincomparisontothecontralateraleyes，thelens—treatedeyesofGroupIII、IVandVbecamemyopic(averagedat一358D一167Dand239Drespectively

7、)andelongated(averagedat006mm007rnmand005mmrespectively)WhiletherewasnorelativemyopiainotherthreegroupsScleraofrelativemyopiceyeswassignificantlythinnerthanthecontralateraleyesHistologicalexaminationrevealednoevidenceofg

8、rosstoxiceffectsatthedoseeriectiveininhibitinginducedaxialmyopiaConclusionsf1)ConcaveIenseswithcertainpowerCanjnduceexperimentalaxialmyopiainguineapigs，whichcouldbeusedasaneffectiveandeconomicalmodelmammalinlensinducedmy

9、opiastudyr2)LensinducedmyopiaiStheconsequenceofposteriorscleraexpandingandthinning，whichisregulatedbyavisualguidedanddependentnegativefeedbackmechanism(3)TopicallyusedselectiveMIreceptorantagonist——^Direnzepineeffectivel