PDCD5、Survivin、p53、Tip60在宮頸上皮內(nèi)瘤變及宮頸癌的表達(dá)及意義.pdf

1、新疆醫(yī)科大學(xué)碩士學(xué)位論文PDCD5、Survivin、p53、Tip60在宮頸上皮內(nèi)瘤變及宮頸癌的表達(dá)及意義姓名：劉曉蘭申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：外科學(xué)指導(dǎo)教師：馬秀敏201010新疆醫(yī)科大學(xué)醫(yī)學(xué)碩士學(xué)位論文新疆醫(yī)科大學(xué)醫(yī)學(xué)碩士學(xué)位論文—2—ExpressionofPDCD5，Survivin，p53Tip60proteintheirsignificanceinCINCervixCancerPostgraduate:LIUXiaoLanT

2、ut:ProfessMAXiuMingAbstractObjective:TostudytherelationshipoftheexpressionsofPDCD5SurvivinTip60p53inCINcervixcancer.Methods:TheexpressionofPDCD5SurvivinTip60p53wasexaminedbyimmunohistochemicalin49CIN39cervicalcarcinomas2

3、0nmalcervixtissues.Results:1)ThepositiveexpressionofPDCD5was100%?100%?81.25%?61.11%?10.25%innmalcervixtissuesCINⅠ?Ⅱ?Ⅲcervicalcarcinomarespectivelythedifferencewasstatisticallysignificant?nmalcervixtissuesCINⅠCINⅡCINⅢther

4、ewasnoobviousdifference.ThepositiveexpressionrateofPDCD5proteininesophagealcarcinomawassignificantlycrelatedwithtumdifferentiation(P＜0.05)2)ThepositiveexpressionofSurvivinwas0?40%?50%?72.22%?82.05%innmalcervixtissuesCINⅠ

5、?Ⅱ?ⅢcervicalcarcinomarespectivelyinnmalcervixtissuesCINcervicalcarcinomarespectivelythedifferencewasstatisticallysignificant?CINⅠCINⅡCINⅢcervicalcarcinomatherewasnoobviousdifference.Significantsurvivinexpressionwasnotedi

6、ncancerpatientswithlymphnodemetastasis(P＜0.01)theclinicopathologicaltypes(P＜0.05)3)ThepositiveexpressionofTip60was65%?60%?75%?72.22%?76.92%innmalcervixtissuesCINⅠ?Ⅱ?Ⅲcervicalcarcinomarespectivelynmalcervixtissues?CINⅠⅢce

7、rvicalcarcinomatherewasnoobviousdifference4)Thepositiveexpressionofp53was61.53%incervicalcarcinomainnmalcervixtissuesnegativethedifferencewasstatisticallysignificant5)TheexpressionofTip60waspositivelycrelatedwithp53prote

8、in.Conclusion:ExpressionofPDCD5?Survivin?Tip60p53abnmalexpressionofthemmaybeinvolvedintheoccurrencedevelopmentofcervicalcancer.Itwasspeculatedthattheremaybeacommontranionmechanismwhichconstructedmultiplepathwaysincancer.