Hp感染影響不同胃粘膜病變中MMP-2表達的相關(guān)性研究.pdf

1、天津醫(yī)科大學碩士學位論文Hp感染影響不同胃粘膜病變中MMP2表達的相關(guān)性研究姓名：任建麗申請學位級別：碩士專業(yè)：內(nèi)科學（消化系病）指導教師：張志廣20070501天津醫(yī)科大學碩士研究生學位論文ABSTRACTOBJECTIVE：TodetecttheexpressionofMMP一2andHpyloristateindifferentgastricmucosalesions，thatisgeneralpopulation，miid、mo

2、destandseveredysplasiapatientsandgastriccancerpatientsTostudytheeffectofHpyloriinfectiononMMP一2expressionindifferentgastricmacosalesionsandontheinvasionandmetastasisofgastriccancerMETHOD：Atotalof293caseswereavailablefort

3、hestudyincluding52casesofchronicsuperficialgastritistoserveascontrolgroup，71casesofmilddysplasia，74casesofmodestandseveredysplasiaand96casesofgastriccarcinoma：HpyloriwasdeterminedwithGiemsastainingmethod，rapidureasetesta

4、nd1’Cureasebreathtest：Streptavidin—peroxidase(SP)immunohistochemicalmethodwasusedtodetecttheexpressionofMMP一2indifferentgastricmucosalesionsforthepurposeofanalyzingtheeffectofHpyloriinfectiononMMP一2expressionRESULTS：NoMM

5、P一2wasexpressedincontrolgroupThepositiverateofMMP一2expressioninmild、modestandseveredysplasiaandgastriccarcinomawere493％、703％and875％respectivelyThepositiverateofMMP一2expressioningastriccarcinomawassignificantlyhigherthant

6、hatinchronicsuperficialgastritis(P001)andthatinmild、modestandseveredysplasia(PO01)Inmodestandseveredysplasiathepositiverateof刪P一2expressionwassignificantlyhigherthanthatinmilddysplasia(PO01)aswellasincontrolgroup(PO01)In

7、miId、modestandseveredysplasiaandgastriccarcinomathepositiverateofMMP一2expressionwithHpyloriinfection(615％、805％、948％)weresignificantlyhigherthanthatwithoutHpyloriinfection(344％、576％、763％)respectively(PO05)TheincidenceofIy