急性冠狀動(dòng)脈綜合征患者血清白細(xì)胞介素-37(IL-37)水平及其臨床意義.pdf

1、Objective：Inflammation plays a major role at all stages of the atherosclerosis process from the early events whereby leukocytes are recruited at sites of subendothelial LDL cholesterol accumulation to the late events,whe

2、n plaque rupture occurs,leading to thrombus formation and adverse acute coronary events.Interleukin-37(IL-37) is a new anti-inflammatory cytokine of the interleukin-1 family and shown a fundamental inhibitor of innate im

3、munity.However,the role of Interleukin-37(IL-37) in the modulation of the atherosclerosis process remains unknown.Therefore,we investigated the serum level of interleukin(IL)-37 in patients with acute coronary syndrome.<

4、br>　　Materials and Methods:
　　A total of 125 patients were enrolled in the study.30 patients with Myocardial Infarction (MI)and 30 patients with Unstable Angina (UA) as Acute Coronary Syndrome (ACS),30 patients with S

5、table Angina (SA) and 35 subjects with no history of ischemic heart disease as normal control(NC).The patients were grouped on the basis of electrocar diographic (ECG) changes,serumcardiac enzymes elevation and angiograp

6、hically documented coronary artery stenosis.MI patients had ST changes,T wave inversion or both and serum cardiac enzyme(troponin>0.01nm/ml) elevation.UA patients are grouped on the basic of Braunwald classification with

7、 ST segment changes but no cardiac troponin elevation.SA patients hadtypical angina symptoms and ≥50％ diameter stenosis in ≥1 coronary artery at the coronarycatheterization and 35 healthy individuals for normal control g

8、roup (NC;n=35).
　　Results:
　　The serum level of IL-37 in acute coronary syndrome (ACS) patients was significantly lower compared with Stable Angina (SA) group and normal control (NC) group.The mean serum level of I

9、L-37 in ACS group was 34.36±26.78,SA was 118.76±69.55 and NC was 124.36±76.36pg/ml.The serum level of IL-37 in SA patients was not significantly differing from NC.The serum levels of IL-37 influence by traditional risk f

10、actors of cardiovascular disease.The smoker and diabetes patients had lower level of serum IL-37 compared with nonsmoker and nondiabetic.Hypertension,dyslipidemia and male gender had not significant association with seru

11、m level of IL-37.The effect of medication on serum level of IL-37 showed that statins increases serum level of IL-37 compared with non-statin.The Aspirin,Angiotensin-converting enzyme inhibitor (ACEI),beta-blockers, Calc

12、ium channel blockers and Nitrate had no effect on serum level of IL-37 inACS patients.
　　Conclusion:
　　Patients with acute coronary syndrome had significantly lower serum concentrations of IL-37 compared with those

13、 who has stable angina.This suggests that decreased serum level of IL-37 concentration may be associated with inflammation,plaque instability and cardiovascular event.Traditional risk factors such as smoking and diabetes