基于多信息融合建立基因調(diào)控網(wǎng)絡(luò)

1、華中科技大學(xué)碩士學(xué)位論文基于多信息融合建立基因調(diào)控網(wǎng)絡(luò)姓名：何東申請學(xué)位級別：碩士專業(yè)：計算機應(yīng)用技術(shù)指導(dǎo)教師：周艷紅20070530IIAbstractConstructinggeneregulatywkisoneofthemostchallengingissuesinthepostgenomeresearchthedepthofwhichnotonlyenrichesourunderstingofthemechanismofcell

2、ularprocessesfurthersthecauseofdiseasebutalsodevelopsthetreatmentofdiseasemanufactureofgeicpharmacy.Thestudymainlyfocusesonthedesignofeffectivecomputationalmethodwhichisestablishedfromtheenhancementoftheaccuracyefficienc

3、yofalgithminconstructingthegeneregulatywk.Thisarticlecarriesonthefollowingseveralaspects.FirstlyinspiredbythebottomtoupwkconstructstrategyweconductedastudyoftheregulatyrelationshipbetweentheTFTGpairbasedonthegeneexpressi

4、ondata.Accdingtotheacteristicsofrealisticproblemswedevisedanewclassifiedalgithmwhichwasshownsuperipredictionprecisionoverothermatureclassifiedmethods.Furthermetorevealthemechanismofgeneregulatywksanewmethodwasfirstlyprop

5、osedtoidentifysynergistictranionalfactsbyintegratinggeneexpressiondatawithChIPchipdata.thenthecooperativeTFsinvolvedintheyeastcellcyclewasanalyzed.Asaconsequencemethanhalfofourpredictedresultswereeitherconfirmedbyliterat

6、ureevidencescompliedwiththeresultsannouncedbypreviouscomputationalmethods.SecondlybasedontheframewkofBayesianwkintegrationofdiversegenomicdataweproposedanovelmethodtoconstructgeneregulatywkswhichcanavoidthedisadvantageso