妊娠期肝內(nèi)膽汁淤積癥對(duì)新生兒體格行為中樞神經(jīng)的影響及川芎嗪的干預(yù).pdf

1、，H‘：020分類(lèi)號(hào)：R21生=255B222：!密級(jí)：公玨學(xué)號(hào)代碼：!Q2駐學(xué)號(hào)：Q!』Q32東南大學(xué)碩士學(xué)位論文妊娠期肝內(nèi)膽汁淤積癥對(duì)新生兒體格行為中樞神經(jīng)的影響及川芎嗪的干預(yù)研究生姓名：導(dǎo)師姓名：申請(qǐng)學(xué)位級(jí)別醫(yī)堂亟學(xué)科專(zhuān)業(yè)名稱(chēng)』L整論文提交日期2鯉生且2自學(xué)位授予單位丕直太堂答辯委員會(huì)主席塞韶墮救援論文答辯日期2壘Q生題!g旦學(xué)位授予日期2壘生且旦評(píng)閱人筮蕓差熬援王篷墮熬援2005年06月20曰東南大學(xué)顧士學(xué)位論文Abstract

2、sT“Ie：Thepooroutcomeofpregnantwomenwithintrahepaticcholestasis(ICP)duringpregnancyontheirnewborns’developmentofthebodyandbehaveandcentralnervoussystemandligustrazill’SefrectPostgraduate：LiuJingProfessor：JiangLiUniversity

3、：SoutheastUniversityobjective：1ToexplorethepooroutcomeinICPbyobservingneuronspecificenolase(NSE)andCKBBinneonatalumbilicalvein，inadditiontothenewborns’developmentofthebodyandbehaveinsuchgroupsasnormalwhosemotherswereheal

4、thyandabnormalwhosemothersweresufferedfromICPduringpregnancy2InordertoevaluateLigustrazin’SeffectonimprovingtheprognosisofthosenewbornswhosemothersweresufferedfromICPduringpregnancy，treatedbyLigustrazin，weexaminedNSEandC

5、KBBinserumindifferentgroupsMethods：1Allpatientsweredividedintothemildgroup，themoderateone，andthesevereoneaccordingtothemothers’diagnosisstandardsAllpatients’weight，length，headcircumferenceandchestcircumferencewereinvesti

6、gatedandcomparedwiththemofthecontrolgroup2NSEandCKBBinneonatalumbilicalveinwereexaminedinallpatientsandcomparedwiththemofthecontrolgroup3Thepatientsinthemoderategroupandthesevereonewereconductedneurologicalbehaviorofnewb

7、ornassessment(NBNA)at3and10daysold4ThenewbornswithhypoxicischemicbraindamagewhosemothersweresufferedfromsevereICPwerehospitalizedinpediatricdepartmentAllofthemweredividedintoGroupAandBGroupAWastreatedbytraditionalmethod：

8、citicolin(CDPC)，mannitol，luminalbyintravenousdripGroupBwasmanagedbyLigustrazininadditiontotraditionalmethodAfter7daysNSEandCK—BBwereinvestigatedResults：1Thelengthinthemoderategroupandthesevereonewassignificantlyshorterth

9、anthatinthemildgroupandlhecontrolgroup；theheadandthechestcircumferenceandweightinseveregroupweresignificantlydifferentfromthatinthecontrolgroup2NSEandCKBBweresignificantlydifferentindifferentgroups3TheNBNAinthemoderategr

10、oupWasrespectively315：L354=35at3daysoldand35_34247at10daysoldshowingmildbraininjure；whiletheNBNAintheseveregroupWasrespectively215463=35at3daysoldand3152422=35at10daysoldshowingseverebraininjure4NSEandCKBBinthegroupBwere

11、significantlylowerthanthatinthegroupA(P005)Conclusion：1ThemoderateICPandthesevereICPhadbadeffectONnewborns’bodydevelopment，themoreseveretheworst2NSEandCKBBinthemoderateICPgroupandthesevereICPonesignificantlyincreased_3NB

12、NAaswellascranialCTscanningNSE、CK—BBmightbeanearlysigninevaluatingtheprognosis4LigustrazincanmakeNSE、CKBBdecreaseandprotectnewbornsfromneonatalhypoxicandischemieinjurebecauseofIcPKeywords：ICP；bodydevelopment；NSE；CK—BB；Li