實(shí)驗(yàn)細(xì)胞資源平臺(tái)通過國家認(rèn)定

1、<p>　　A.     Positions and Honors. </p><p><b>　　Positions</b></p><p>　　1993-1995Research Associate, Immunology Program, Wistar Institute, Philadelphia,

2、 PA</p><p>　　1996 –1999 Senior Scientist, Immunology Program, Wistar Institute, Philadelphia, PA</p><p>　　3/2000-3/2004Assistant Professor, Department of Microbiology and Immunology, Weill

3、Medical College of Cornell University (WMCCU).</p><p>　　4/2004-09/2007 Associate Professor, Department of Microbiology and Immunology, (WMCCU).</p><p>　　12/2004-presentAssociate Director, Host

4、 Defenses Course, (WMCCU).</p><p>　　10/2007-presentProfessor with tenure, Department of Microbiology and Immunology, (WMCCU).</p><p>　　12/2007-presentDepartment of Pediatrics, faculty mentor f

5、or critical care medicine fellows (WMCCU).</p><p>　　9/2009-presentChairman, Admission to Candidacy Examination (ACE) Committee, Graduate Program in Immunology and Microbial Pathogenesis, Weill Graduate Scho

6、ol of Medical Sciences, Cornell University.</p><p><b>　　Honors</b></p><p>　　1983-1987Predoctoral Studentship from Tang Kakji Trust.</p><p>　　1985 –1987 Overseas S

7、tudent Award by the British Council.</p><p>　　1998                          &

8、#160;             Young Investigators Award by International Cytokine Society.</p><p>　　1999-2004Howard Temin Award (NCI/NIH)</p><p>

9、;　　Editorial Responsibilities</p><p>　　2002-presentMember, Faculty 1000 (Immunology).</p><p>　　2002-presentAdvisory Editorial Board of the Journal of Experimental Medicine </p><

10、;p>　　2005-presentAdvisory Editorial Board of Annual Review of Biomedical Science</p><p>　　2007-present Editorial Board, Journal of the International Society of Interferon and Cytokine Resea

11、rch</p><p>　　07/2009-presentAssociate Editor, The Journal of Immunology</p><p>　　12/2009-presentAdvisory Editorial Board of Cellular and Molecular Immunology</p><p>　　Professional

12、 Membership</p><p>　　2004-present American Association of Immunologists (AAI)</p><p>　　2002-present International Society for Interferon and Cytokine Research </p><p>　　B.

13、     Selected peer-reviewed publications (in reverse chronological order)</p><p>　　1.      Lu, TT, Kim, H, Ma, X. 2011. IL-17, a new kid on the block of tertiary

14、 lymphoid organs. Mol. Cell. Immunol. 2011 Sep 19. doi: 10.1038/cmi.2011.34. [Epub ahead of print] </p><p>　　2.      Yin, F, Banerjee, R, Thomas, B, Zhou, P, Qian, L, Jia, T, Ma, X,

15、Ma, Y, Iadecola, C, Beal, MF, Nathan, C and Ding, H. 2010. Exaggerated Inflammation, Impaired Host Defense and Neuropathology in Progranulin-Deficient Mice. J. Exp. Med. 207(1):117-128.</p><p>　　3. 

16、0;    Jiao, X., Katiyar, S., Willmarth, NE, Liu, M., Flomenberg, N., Ma, X., Lisanti, MP, Pestell, RG. 2010. C-jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion. J. Bi

17、ol. Chem. 285(11):8218-8226.</p><p>　　. J. Immunol. 184:3718-3724.</p><p>　　5.       Zhang, Y. Ma, X. 2010. Triptolide Inhibits IL-12/IL-23 Gene Expression in An

18、tigen-presenting Cells via CCAAT/enhancer-Binding Protein Alpha. J. Immunol. 184:3866-3877.</p><p>　　Nature Immunology. 10(5):471-479.</p><p>　　J Immunol. 2009 Jul 15;183(2):1110-1119.</p>

19、;<p>　　leishmania spp.-infected macrophages. J. Parasitol., 94(1):84–93.</p><p>　　9.Chung, E., Liu, J., Homa, Y., Zhang,Y., Brendolan, A., Saggese, M., Han, J., Silverstein, R., Selleri, L., X.Ma. 20

20、07. Interleukin-10 Expression in Macrophages during Phagocytosis of Apoptotic Cells Is Mediated by homeoproteins Pbx-1 and Prep-1. Immunity. 27:952-964.</p><p>　　10.Liu, J., Guan, X., X. Ma. 2007. Regulatio

21、n of IL-27 p28 gene expression in macrophages through MyD88- and Interferon--mediated pathways. J Exp Med. 204:141-152.</p><p>　　11.Park-Min, K., Serbina, N., Yang, W., X. Ma, Krystal, G., Neel, BJ, Nutt, S

22、L, Hu, X., and Ivashkiv, LB. 2007. FcγRIII-Dependent Inhibition of Interferon-γ Responses Mediates Suppressive Effects of Intravenous Immune Globulin. Immunity. 26, 67-78.</p><p>　　12.Chung, EY, Liu, J., Zh

23、ang, Y., and X. Ma. 2007. Differential Expression in Lupus-associated IL-10 Promoter Single-nucleotide Polymorphisms Is Mediated by Poly(ADP-ribose) Polymerase 1. Genes & Immunity. 8(7):577-589.</p><p>　

24、　?B nuclear translocation. J. Interferon & Cytokine Res. 27(9):799-808.</p><p>　　14.Werts, C., le Bourhis, L., Liu, J., Magalhaes, JG., Fritz, JH., Stockinger, S., Decker, T., Philpott, DJ., Ma, X., and

25、 Girardin. SE. 2007. Nod1 and Nod2 induce CCL5/RANTES through the NF-κB pathway. Eur. J. Immunol. 37(9):2499-2508.</p><p>　　15.Murray, H.W., C.W. Tsai, J. Liu, and X. Ma. 2006. Responses to Leishmania donov

26、ani in Mice Deficient in Interleukin-12 (IL-12), IL-12/IL-23, or IL-18. Infect Immun 74:4370-4374.</p><p>　　16.Murray, H.W., Z. Xiang, and X. Ma. 2006. Responses to Leishmania donovani in mice deficient in

27、both phagocyte oxidase and inducible nitric oxide synthase. Am J Trop Med Hyg 74:1013-1015.</p><p>　　17.Murray, H.W., C.W. Tsai, J. Liu, and X. Ma. 2006. Visceral Leishmania donovani Infection in Interleuki

28、n-13-/- Mice. Infect Immun 74:2487-2490.</p><p>　　J Biol Chem 281:19188-19195.</p><p>　　19.Liu, J., Mankani, G., Shi, X., Meyer, M., Cunningham-Runddles, S., Ma, X., Sun, Z. 2006. The Circadian

29、 Clock Period 2 Gene Regulates IFN-gamma production of NK Cells in Host Response to LPS-induced Endotoxic Shock. Infect Immun 74:4750-4756.</p><p>　　20.Wu, Y., Z. Liu, Z. Xiang, C. Zeng, Z. Chen, X. Ma, an

30、d L. Li. 2006. Obesity-related glomerulopathy: insights from gene expression profiles of the glomeruli derived from renal biopsy samples. Endocrinology 147:44-50.</p><p>　　21.Tripathi, P., R. Madan, C. Chou

31、gnet, S. Divanovic, X. Ma, L.M. Wahl, T. Gajewski, C.L. Karp, and D.A. Hildeman. 2006. An adenoviral vector for probing promoter activity in primary immune cells. J Immunol Methods 311:19-30.</p><p>　　Cancer

32、 Research 65:10578-10584.</p><p>　　23.Shan, D., L. Chen, J.T. Njardarson, C. Gaul, X. Ma, S.J. Danishefsky, and X.Y. Huang. 2005. Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in

33、mice. Proc Natl Acad Sci U S A 102:3772-3776.</p><p>　　24.Murray, H.W., K.C. Flanders, D.D. Donaldson, J.P. Sypek, P.J. Gotwals, J. Liu, and X. Ma. 2005. Antagonizing deactivating cytokines to enhance host

34、defense and chemotherapy in experimental visceral leishmaniasis. Infect Immun 73:3903-3911.</p><p>　　J Biol Chem 280:24347-24355.</p><p>　　J Immunol 174:3484-3492.</p><p>　　27.Shi,

35、 X., S. Cao, M. Mitsuhashi, Z. Xiang, and X. Ma. 2004. Genome-wide analysis of molecular changes in IL-12-induced control of mammary carcinoma via IFN-gamma-independent mechanisms. J Immunol 172:4111-4122.</p><

36、;p>　　28.Shi, X., J. Liu, Z. Xiang, M. Mitsuhashi, R.S. Wu, and X. Ma. 2004. Gene expression analysis in Interleukin-12-induced suppression of mouse mammary carcinoma. Int J Cancer 110:570-578.</p><p>　　2

37、9.Mitsuhashi, M., J. Liu, S. Cao, X. Shi, and X. Ma. 2004. Regulation of interleukin-12 gene expression and its anti-tumor activities by prostaglandin E2 derived from mammary carcinomas. J Leukoc Biol 76:322-332.</p&

38、gt;<p>　　J Biol Chem 279:18451-18456.</p><p>　　J Biol Chem 279:55609-55617.</p><p>　　32.Liu, J., Z. Xiang, and X. Ma. 2004. Role of IFN regulatory factor-1 and IL-12 in immunological res

39、istance to pathogenesis of N-methyl-N-nitrosourea-induced T lymphoma. J Immunol 173:1184-1193.</p><p>　　Immunity 21:643-653.</p><p>　　34.Cao, S., Xiang, Z., and Ma, X. 2004. Global Gene Express

40、ion Profiling in Interleukin-12-induced Activation of CD8+ Cytotoxic T Lymphocytes against Mouse Mammary Carcinoma. Cellular and Molecular Immunology 1:357-366.</p><p>　　35.Murray, H.W., A.L. Moreira, C.M.

41、Lu, J.L. DeVecchio, M. Matsuhashi, X. Ma, and F.P. Heinzel. 2003. Determinants of response to interleukin-10 receptor blockade immunotherapy in experimental visceral leishmaniasis. J Infect Dis 188:458-464.</p>&l

42、t;p>　　36.Liu, J., S. Cao, L.M. Herman, and X. Ma. 2003. Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. J Exp

43、Med 198:1265-1276.</p><p>　　37.Kim, S.J., D. Gershov, X. Ma, N. Brot, and K.B. Elkon. 2002. I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding

44、by natural immunoglobulin M antibodies and complement activation. J Exp Med 196:655-665.</p><p>　　J Immunol 169:5715-5725.</p><p>　　J Immunol 166:4498-4506.</p><p>　　40.Byrnes, A.A

45、., X. Ma, P. Cuomo, K. Park, L. Wahl, S.F. Wolf, H. Zhou, G. Trinchieri, and C.L. Karp. 2001. Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity. Eur J Immunol 31:2026-203

46、4.</p><p>　　41.Becker, C., S. Wirtz, X. Ma, M. Blessing, P.R. Galle, and M.F. Neurath. 2001. Regulation of IL-12 p40 promoter activity in primary human monocytes: roles of NF-kappaB, CCAAT/enhancer-binding

47、protein beta, and PU.1 and identification of a novel repressor element (GA-12) that responds to IL-4 and prostaglandin E(2). J Immunol 167:2608-2618.</p><p>　　J Immunol 165:271-279.</p><p>　　43.

48、Ma, X., J. Sun, E. Papasavvas, H. Riemann, S. Robertson, J. Marshall, R.T. Bailer, A. Moore, R.P. Donnelly, G. Trinchieri, and L.J. Montaner. 2000. Inhibition of IL-12 production in human monocyte-derived macrophages by

49、 TNF. J Immunol 164:1722-1729.</p><p>　　44.Pardoux, C., X. Ma, S. Gobert, S. Pellegrini, P. Mayeux, F. Gay, G. Trinchieri, and S. Chouaib. 1999. Downregulation of interleukin-12 (IL-12) responsiveness in hu

50、man T cells by transforming growth factor-beta: relationship with IL-12 signaling. Blood 93:1448-1455.</p><p>　　45.Na, S.Y., B.Y. Kang, S.W. Chung, S.J. Han, X. Ma, G. Trinchieri, S.Y. Im, J.W. Lee, and T.S

51、. Kim. 1999. Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB. J Biol Chem 274:7674-7680.</p><p>　　46.Ma, X., H. Riemann, G. Gri,

52、and G. Trinchieri. 1998. Positive and negative regulation of interleukin-12 gene expression. Eur Cytokine Netw 9:54-64.</p><p>　　47.Karp, C.L., M. Wysocka, X. Ma, M. Marovich, R.E. Factor, T. Nutman, M. Arm

53、ant, L. Wahl, P. Cuomo, and G. Trinchieri. 1998. Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance. Eur J Immunol 28:3128-3136.</p><p>　　J Biol Chem 273:643

54、1-6438.</p><p>　　49.Coughlin, C.M., K.E. Salhany, M.S. Gee, D.C. LaTemple, S. Kotenko, X. Ma, G. Gri, M. Wysocka, J.E. Kim, L. Liu, F. Liao, J.M. Farber, S. Pestka, G. Trinchieri, and W.M. Lee. 1998. Tumor

55、cell responses to IFNgamma affect tumorigenicity and response to IL-12 therapy and antiangiogenesis. Immunity 9:25-34.</p><p>　　50.Aste-Amezaga, M., X. Ma, A. Sartori, and G. Trinchieri. 1998. Molecular mec

56、hanisms of the induction of IL-12 and its inhibition by IL-10. J Immunol 160:5936-5944.</p><p>　　51.Sartori, A., X. Ma, G. Gri, L. Showe, D. Benjamin, and G. Trinchieri. 1997. Interleukin-12: an immunoregul

57、atory cytokine produced by B cells and antigen-presenting cells. Methods 11:116-127.</p><p>　　52.Moller, D.R., M. Wysocka, B.M. Greenlee, X. Ma, L. Wahl, G. Trinchieri, and C.L. Karp. 1997. Inhibition of hu

58、man interleukin-12 production by pentoxifylline. Immunology 91:197-203.</p><p>　　53.Moller, D.R., M. Wysocka, B.M. Greenlee, X. Ma, L. Wahl, D.A. Flockhart, G. Trinchieri, and C.L. Karp. 1997. Inhibition of

59、 IL-12 production by thalidomide. J Immunol 159:5157-5161.</p><p>　　54.Ma, X., M. Neurath, G. Gri, and G. Trinchieri. 1997. Identification and characterization of a novel Ets-2-related nuclear complex impli

60、cated in the activation of the human interleukin-12 p40 gene promoter. J Biol Chem 272:10389-10395.</p><p>　　55.Ma, X., M. Aste-Amezaga, G. Gri, F. Gerosa, and G. Trinchieri. 1997. Immunomodulatory function

61、s and molecular regulation of IL-12. Chem Immunol 68:1-22.</p><p>　　56.Ma, X., J.M. Chow, G. Gri, G. Carra, F. Gerosa, S.F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is

62、primed by interferon gamma in monocytic cells. J Exp Med 183:147-157.</p><p>　　57.Ma X, Aste-Amezaga M Trinchieri G. Regulation of interleukin-12 production. Ann N Y Acad Sci 1996; 795: 13-25.</p>&l

63、t;p>　　Ann N Y Acad Sci 1996; 795: 357-60.</p><p>　　59.Chehimi J, Ma X, Chouaib S, Zyad A, Nagashunmugam T, Wojcik L, Chehimi S, Nissim L Frank I. Differential production of interleukin 10 during human im

64、munodeficiency virus infection. AIDS Res Hum Retroviruses 1996; 12: 1141-9.</p><p>　　60. Aste-Amezaga M, Ma X Trinchieri G. Regulation by interleukin-10 of Staphylococcus aureus- and lipopolysaccharide-induc

65、ed interleukin-12 gene expression in human peripheral blood mononuclear cells. Ann N Y Acad Sci 1996; 795: 319-20.</p><p>　　61.Ma X, D'Andrea A, Kubin M, Aste-Amezaga M, Sartori A, Monteiro J, Showe L,

66、Wysocka M Trinchieri G. Production of interleukin-12. Res Immunol 1995; 146: 432-8.</p><p>　　62.D'Andrea A, Ma X, Aste-Amezaga M, Paganin C Trinchieri G. Stimulatory and inhibitory effects of interleuki

67、n (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. J Exp Med 1995; 181: 537-46.</p><p>　　63.Cassatel

68、la MA, Meda L, Gasperini S, D'Andrea A, Ma X Trinchieri G. Interleukin-12 production by human polymorphonuclear leukocytes. Eur J Immunol 1995; 25: 1-5.</p><p>　　64.Chehimi J, Starr SE, Frank I, D'A

69、ndrea A, Ma X, MacGregor RR, Sennelier J Trinchieri G. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J Exp Med 1994; 179: 1361-6.</p><p>　　65.Ma X, Saitoh N Curtis PJ

70、. Purification and characterization of a nuclear DNA-binding factor complex containing topoisomerase II and chromosome scaffold protein 2. J Biol Chem 1993; 268: 6182-8.</p><p>　　66.D'Andrea A, Aste-Ame

71、zaga M, Valiante NM, Ma X, Kubin M Trinchieri G. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Ex

72、p Med 1993; 178: 1041-8.</p><p>　　67.Ma X, Fraser P Curtis PJ. A differentiation stage-specific factor interacts with mouse carbonic anhydrase form I gene and a conserved sequence in mammalian beta-globin g

73、enes. Differentiation 1991; 47: 135-41.</p><p>　　68. Clark AJ, Chave-Cox A, Ma X. Bishop JO. Analysis of mouse major urinary protein genes: variation between the exonic sequences of group 1 genes and a compa

74、rison with an active gene out with group 1 both suggest that gene conversion has occurred between MUP genes. EMBO J 1985; 4: 3167-71.</p><p>　　Books, Book Chapters and Reviews</p><p>　　1. Zhang

75、, Y., Kim, HJ, Yamamoto, S., Kang, X., Ma, X. 2010. Regulation of Interleukin-10 Gene Expression in Macrophages Engulfing Apoptotic Cells. J. Interfron & Cytokine Res. 30(3):1-9</p><p>　　2.Yamamoto, S.

76、, Ma, X. 2009. Role of Nod2 in the development of Crohn’s disease. Microbes and Infection. 11(12):912-918.</p><p>　　3. Chung, E.Y., S.J. Kim, and X.J. Ma. 2006. Regulation of cytokine production during pha

77、gocytosis of apoptotic cells. Cell Res 16:154-161.</p><p>　　4.Liu, J., Cao, S., Kim, S.J., Chung, E.Y., Homma, Y., Jimenez, V., Ma, X. 2005. Interleukin-12: an update on its immunological activities, signal

78、ing and regulation of gene expression. Current Immunology Reviews 1:119-137.</p><p>　　5. Kim, S., E.Y. Chung, and X. Ma. 2005. Immunological Consequences of Macrophage-Mediated Clearance of Apoptotic Cells.

79、 Cell Cycle 4:231-234.</p><p>　　6.Kim, S.J., Gershov, D., Ma, X., Brot, N., Elkon, E.L. 2003. Opsonization of Apoptotic Cells and its Effect on Macrophage and T cell Immune Responses. Ann N Y Acad Sci. 987:

80、68-78.</p><p>　　7. Xiang, Z., Yang, Y., Ma, X., and Ding, W. 2003. Microarray Expression Profiling: Analysis and Applications. Current Opinions in Drug Discovery and Development 6(3):384-395.</p><

81、;p>　　8.Ma, X. 2001. TNF- and IL-12: a balancing act in macrophage functioning. Microbes and Infection. Forum in Immunology: inhibitory receptors of mononuclear phagocytes. Institut Pasteur. 3(2):121-9.</p>

82、<p>　　9. Ma. X. and Trinchieri G. 2001. Regulation of Interleukin-12 production in antigen-presenting cells. Advances in Immunology. 79:55-92.</p><p>　　10. Ma. X. and Montaner, L.J. 2000. HIV-1 in

83、fection: proinflammatory response and IL-12 production by macrophages. J Leukoc Biol. 68(3):383-90.</p><p>　　11.Ma, X., Reimann, H., Gri, G., and Trinchieri, G. 1998. Positive and negative regulation of

84、Interleukin-12 gene expression. Eur Cytokine Netw. 9(3 Suppl):54-64.</p><p>　　12.Neurath, M., Ma, X., and Pettersson, S. (262 pages). 1997. DNA-protein interactions. Spectrum Akadenvischer Verlag, Heide

85、lberg, Berlin, Oxford.</p><p>　　13. Ma X., Aste-Amezaga M, Gri G, Gerosa F, Trinchieri G. 1997. Immunomodulatory functions and molecular regulation of IL-12. Chem Immunol. 68:1-22. </p><p>　　

86、C. Research Grant Support </p><p><b>　　Current</b></p><p>　　1R01AI072149-01A2Ma (PI)09/26/09-08/31/12</p><p>　　NIH/NIAID“Crohn's disease-assoc

87、iated NOD2 Mutants”</p><p>　　R01 AI083219 Murray (PI), Ma (co-PI)02/05/10-01/31/15</p><p>　　NIH/NIAID“Immunochemotherapy in Visceral Leishmaniasis”</p><p>　　1R56AI0

88、95512-01Ma (PI)08/15/11-07/31/12</p><p>　　NIH/NIAID“Regulation of IL-10 Gene Expression and Host Septic Response by Progranulin”</p><p>　　Komen Breast Cancer Foundation Ma

89、 (PI)06/01/09-05/31/12</p><p>　　“Role and mechanism of chemokine RANTES in immunity against breast cancer”</p><p>　　Crohn’s & Colitis Foundation of AmericaMa (PI)01/01/1

90、1-03/31/12</p><p>　　“Regulation of inflammatory cytokine expression by NOD2 via a novel winged helix/forkhead nuclear factor”</p><p>　　Completed within the past three years:</p><p>

91、　　?         R21 AT004349(PI: Ma)09/30/07-08/31/09</p><p>　　NIH/NCCAM, “Mechanism of Modulation of Interleukin-12 Production by Triptolide”</p>

92、<p>　　?         R01 AI045899(PI : Ma)08/01/04-07/31/09 </p><p>　　NIH/NIAID, “Cytokine Production during Phagocytosis of Apoptotic Cells”<

93、/p><p>　　This project investigated how apoptotic cell-derived signals regulate IL-12 and IL-10 gene expression in professional phagocytes.</p><p>　　?