西北農(nóng)林科技大學(xué)應(yīng)用化學(xué)專業(yè)本科生畢業(yè)論文（設(shè)計(jì)）_第1頁
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1、西北農(nóng)林科技大學(xué)應(yīng)用化學(xué)專業(yè)本科生畢業(yè)論文（設(shè)計(jì)）目錄第一章文獻(xiàn)綜述.......................................................................................................................11.1倍半萜化合物的研究背景....................................................

2、........................................11.2兩種倍半萜內(nèi)酯的研究概況........................................................................................11.2.11O乙?；蠡ㄐ不▋?nèi)酯的研究概況.....................................................

3、........11.2.1.11O乙?；蠡ㄐ不▋?nèi)酯的化學(xué)合成.......................................................11.2.1.21O乙酰基大花旋覆花內(nèi)酯的結(jié)構(gòu)修飾.......................................................21.2.2小白菊內(nèi)酯的研究概況....................................

4、....................................................41.2.2.1小白菊內(nèi)酯的化學(xué)合成..................................................................................41.2.2.2小白菊內(nèi)酯的結(jié)構(gòu)修飾：.................................................

5、.............................41.3Heck反應(yīng)的介紹..........................................................................................................61.4立題依據(jù)................................................................

6、........................................................81.5研究目的及意義............................................................................................................8第二章實(shí)驗(yàn)部分.....................................

7、...................................................................................................92.1實(shí)驗(yàn)儀器.................................................................................................................

8、.......92.2實(shí)驗(yàn)材料........................................................................................................................92.31O乙酰基大花旋覆花內(nèi)酯和1，6O，O乙?；蠡ㄐ不▋?nèi)酯的結(jié)構(gòu)修飾...92.3.11O乙?；蠡ㄐ不▋?nèi)酯6OH的酯化修飾..................

9、................................92.3.21，6O，O乙?；蠡ㄐ不▋?nèi)酯13位環(huán)外雙鍵的Heck偶聯(lián)....................92.3.3小白菊內(nèi)酯13位環(huán)外雙鍵的Heck偶聯(lián)..........................................................102.4實(shí)驗(yàn)結(jié)果與討論.....................................

10、.....................................................................102.5衍生物的細(xì)胞毒活性評(píng)價(jià)..........................................................................................14第三章探索部分....................................

11、..................................................................................................153.1探索帶有雜環(huán)的碘代物與1O乙酰基大花旋覆花內(nèi)酯進(jìn)行反應(yīng)的條件............153.2探索帶有雜環(huán)的碘代物與小白菊內(nèi)酯進(jìn)行反應(yīng)的條件.........................................153.3實(shí)

12、驗(yàn)結(jié)果與討論.........................................................................................................15第四章結(jié)語與展望...................................................................................................

13、..............................17參考文獻(xiàn)......................................................................................................................................................18附錄..............................

14、.............................................................................................................20致謝...........................................................................................................

15、...................................................26StructuremodificationcytotoxicactivitystudyingoftwosesquiterpenelactonesAbstract:1OacetylbritannilactoneisasesquiterpeneisolatedfromthemedicinalplantInulabritannicaiso

16、neoftheactiveingredientsofinulaflowerhaveantiinflammatyantitumantibacterialotherpharmacologicaleffects.Currentlythenaturalproductsactasrawmaterialthroughchemicalreactionfstructuralmodificationofderivativesincytotoxicacti

17、vityresearchalsomadegreatprogress.ParthenolideisthemainChinesemedicinewhichextractfromwildchamomilebelongstosesquiterpenelactonecompoundsthroughdifferentmechanismsplayaroleofanticancerinawidevarietyoftumcellsParthenolide

18、hasinhibityeffectonabnmalcellsatthesametimehadnoeffectonthenmalcellstheuniquebiologicalactivityasinflammationcancertreatmenthastheadvantageofpotential.Basedon1OacetylbritannilactoneParthenolideasrawmaterialthroughtheHeck

19、couplingreactionofthe13outsidearingofthedoublebondfstructuralmodificationgettenderivativesby1HNMR、13CNMR、ESIMSXraydiffractionspectrummethodonderivativesfstructuralacterizationthentheevaluationofcytotoxicactivityfsomederi

20、vatives.Theresultsshowedthat:aftersixthhydroxystructuremodificationderivativescytotoxicactivityishigherthanthemotherofderivativesdoublebondbythirteenthoutsideringstructuremodifiedderivativesofcytotoxicactivityislowerthan

21、themotherofderivativesrevealsthesixthhydroxyisnttheactivegroupofsesquiterpenelactonesthethirteenthoutsideringdoublebondistheactivegroupofsesquiterpenelactones.Keywds:1Oacetylbritannilactone；Parthenolide；Heckreaction；cyto

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