P53和P16在喉癌及手術(shù)切緣中的表達(dá)及其臨床意義.pdf

1、中國(guó)協(xié)和醫(yī)科大學(xué)博士學(xué)位論文P53和P16在喉癌及手術(shù)切緣中的表達(dá)及其臨床意義姓名：魏伯俊申請(qǐng)學(xué)位級(jí)別：博士專業(yè)：頭頸腫瘤外科指導(dǎo)教師：屠規(guī)益唐平章1999.6.1P53P16在喉癌和手術(shù)切緣中的表達(dá)及其臨床意義Thestatusofp53andp16examinedbyIHCinthelaryngealsquamouscellcarcinomaandthesurgicalmarginsanditsclinicalsignificanc

2、eABSTRACTItiswidelyacceptedthatthepatientswithpositivesurgicalmargin(s)willpracticearatherpoorprognosiscomparingwiththoseofnegativeoneslargelybecauseofhighriskoflocalrecurrenceInfacteveninthepatientswithSOcallednegatives

3、urgicalmarginsexaminedwiththeroutinepathologicmethods，abouthalfofthemalsosufferfromtheproblemInordertominimizethedangerofrecurrencetreatedafteroperation，IHC(immunohistochemistry)forP16andp53，whichplayaveryimportantrolein

4、carcinogenesis，areexercisedwithapurposeofsomemoreinsightintotheSOcallednegativesurgicalmarginsAnumberof100patientsfromtheHcadandNeckDepartmentinourhospitalfromI980to1992wereincludedinthisstudyAmongthem52caseswereonesWith

5、recurrence，andtheremainderwasselectedasacontrolgroup，inwhichafollow—upforaperiodofatleastfiveyearswasavailableineverycase，Themajorobjectiveofthisstudywastoevaluateanumberofparameterstoestablishtheirrelativeprognosticvalu

6、esinpredictinglocalrecurrenceandregionalordistantmetastasisThepresenceorabsenceofstaininganddepthofcolorwerenotedwhentheresultswereevaluatedMultiplevariablesincludedinourstudyhavebeenanalyzedThisanalysisofmultipleclinica