TGF-β1、Smad4 蛋白和TβRⅡ在膽囊癌發(fā)生與發(fā)展中的作用.pdf

1、河南科技大學(xué)碩士學(xué)位論文TGFβ1、Smad4蛋白和TβRⅡ在膽囊癌發(fā)生與發(fā)展中的作用姓名：何治軍申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：腫瘤學(xué)指導(dǎo)教師：孫君軍@河南科技大學(xué)碩士學(xué)位論文IISubject:TheexpressionofTGFβ1、Smad4TβRIIinthedevelopmentofcarcinomaofgallbladderSpecialty:OncologyName:HEZhijunSupervis:ProfessSUNJunj

2、unABSTRACTObjectiveTestTGFβ1Smad4TβRⅡinthecholecystitisadenomaofgallbladdercarcinomaofgallbladderofexpressiontoinvestigatetherelationshipbetweentheexpressionoftheTGFβ1Smad4TβRⅡthepossiblemechanismsinthedevelopmentofcarci

3、nomaofgallbladder.MethodsImmunohistochemicalSABCmethodwasusedtoexaminetheexpressionofTGFβ1，Smad4TβRⅡin30casesofcarcinomaofgallbladder11caseofadenomaofgallbladder30caseofcholecystitistoAnalysistherelationshipbetweentheexp

4、ressionofTGFβ1Smad4TβRⅡclinicopathologyofcarcinomaofgallbladder.ResultsTheexpressionratesofTGFβ1Smad4TβRⅡincarcinomaofgallbladderwere73.3%(223020%(630)16.7%(530)respectivelyinadenomaofgallbladderwere90.9%（1011）63.7％（711）

5、54.5％（611）incholecystitiswere96.7%(2930)93.3%(2830)90%（2730）.TGFβ1positivityincarcinomaofgallbladderwassignificantlylowerthanincholecystitis(P0.05).Smad4TβRⅡpostivityincarcinomaofgallbladderwerelowerthaninCholecystitis(P

6、0.05).TherewasasignificantrelationshipbetweentheexpressionofTGFβ1clinicalstagetummetastasis(P0.05).TGFβ1positivitywassignificantlylowerincarcinomaofgallbladderofclinicalstageⅠⅡthanthatofstageⅢ－Ⅴ(P0.05)butSmad4TβRⅡwerecon

7、trary.ConclusionThelowexpressionofTGFβ1incarcinomaofgallbladdermayberelatetothecellmalignanttransfmationuncontrolledgrowth.DecreasingexpressionofSmad4TβRⅡincarcinomaofgallbladdermaybethereasonsfescapingthenegativeregulat