胃腺癌組織中p53和NF-κBp65蛋白的表達(dá)及意義.pdf

1、內(nèi)蒙古醫(yī)學(xué)院碩士學(xué)位論文胃腺癌組織中p53和NFκBp65蛋白的表達(dá)及意義姓名：楊曉艷申請學(xué)位級(jí)別：碩士專業(yè)：內(nèi)科學(xué)指導(dǎo)教師：陳春華201005019p53andNF—KBp65proteinexpressionandsignificancesinGastricadenocarcinomaAbstractAimToexplorep53andNF——KBp65proteinexpressioningastricadenocarcinoma

2、andtherelationshipwithclinicalpathologicalfeaturesMethodsImmunohistochemicalStaining(SPmethod)Wasusetodetectedp53andNF—KBp65proteinin100casesofgastricadenocarcinomaand42easesofgastricadenocarcinomabmphnodemetastasisResul

3、tsThepositiverateofp53proteinexpressioningastricadenocarcinomais53％ThepositiverateoflowdifferentiategastricadenocarcinomagradeWasremarkablyhigherthanthatinthehighandmiddledifferentiatedgrade(X2=7486，PO05；X2=1751，P005)The

4、positiverateofNF—KBp65proteiningastricadenocarcinomais58％ThepositiverateoflowdifferentiategastricadenoearcinomagradeWasremarkablyhigherthanthatinthehighandmiddledifferentiatedgrade(x24624，PO05)；ThepositiverateofNF—KBp65p

5、roteinexpressioningastricadenocarcinomawithlymphmetastasisWashigherthanthatwithoutlymphmetastasis(X2=3876，PO05)；ThepositiverateofstagesllI、IVingastricadenocarcino—mawashigherthantheexpressioninstagesI、IIgroup(x2=7436，P00

6、1)；ThereWas110significantdifferenceforNF——KBp65expressionbetweenthedifferentpartsofgastricadeno。carcinomatissueorthedifferentagesgroupsThepositiverateofp53和NF—gBp65respee。tivelyWas3095％and3571％in42casesofbmphnodemetastas