甘油二酯酰基轉(zhuǎn)移酶2（DGAT2）與鵝肥肝TAG合成和分泌的關(guān)系研究.pdf

1、四川農(nóng)業(yè)大學(xué)碩士學(xué)位論文甘油二酯?；D(zhuǎn)移酶2(DGAT2)與鵝肥肝TAG”合成和分泌的關(guān)系研究蘭英指導(dǎo)教師王繼塞夔援學(xué)科專業(yè)動(dòng)塑遺佳直社生鳘殖研究方向盆王遺佳皇盔盒直弛2006年6月’：_AbstractTheliverisamainsiteoflipogenesisinpoultryTheleveloftriglyceride(TAG)inplasmahasamajorrelationwithgrowthofadiposetissue

2、andfattydepositioninpoultryTAGsynthesizedinlivercannotbetransportedbybloodanditgallnotbeutilizedinperipheraltissueuntilitisassembledtolipoproteininfiverandsecretedtobloodintheformofverylowdensitylipoproteintriglyceridc(V

3、LDLTAG)WhenthecapabilityofpreductinofTAGinliverexceedsthecapabilityofsecretingTAGtobloodintheformof(VLDLTAG)，agreatofTAGwoulddepositintheliverwhichcouldresultinhepaticstcatosisThevaluedfattyliverisproductedthroughthelive

4、rsteatosisinducedbyoverfeedingwithaearbohy&atedchcornbaseddietingeeseorducksThereasonoffattyliverinducedbyoverfeedingmaybethedestructionofTAGdynamicbalanceinliverHowever，theconcretemechanismisunclearAsadiacylgycerolaeylt

5、ransferase，makingDAGreact、撕tIlfattyacylcoAtosynthsisTAGisthefunctionmechanismofDGAT2。ThelevelofDGAT2expressionismosthighinthetissuesofvigorousfatmetabolism(suchasliverwhiteadiposetissue)，whichmgansDGAT2playsanimportantro

6、leinlipidmetabolismDGAT2notonlyplaysanimportantroleinTAGsynthesisbutitisessentialforthelifeofanimalsThemouseknockedDGAr2genesoondiedafterbirthSo，inthestudyLandesgoose(whoseperformanceofliverproductisgood)andSichuanwhiteg

7、oose(whoseperformanceofliverproductispoor)areusedasexperimentobjects，andweresearchedtheoverfeedingeffecttobodycomposition(suchasTAGcontentofhepaticlipids)，plamsapaxametor(suchasVLDLandTAGconcentrationinplasma)，thelipidde

8、positdiversityofthetwospeciesofgoosetheeffectofoverfeedingtoDGAT2expressionandactivityandtheinfluenceofDGAr2genetoTAGsynthesisandsecretioninliverThemainresultsarelistedasfollows：1Overfeedingcouldenhancethegrowthofthelive

9、randextrahepaticadiposetissue，butitsmainconn珂叫正onispromotingTAGdepositioninliverandthenresultinhepaticsteatosistoformfattyliverOverfeedingcouldinfulenceVLDL，TAG、Glu、Insulinconcentrationinplasma，butthedegreemayexistdivers