部分性繼發(fā)全面性發(fā)作癲癇的靜息態(tài)功能磁共振研究.pdf

1、中南大學(xué)碩士學(xué)位論文部分性繼發(fā)全面性發(fā)作癲癇的靜息態(tài)功能磁共振研究姓名：謝穎申請學(xué)位級(jí)別：碩士專業(yè)：神經(jīng)病學(xué)指導(dǎo)教師：肖波20110519七年制碩士學(xué)位論文英文摘要ABSTRACTobjectToexplorethefunctionalnetworkandstudytheunderlyingneuro—pathophysiologicalmechanismofthesecondarygeneralizeepilepsy(SGE)byBO

2、LD—fMRIMethod31patientswithSGEand30genderageandeducationmatchedhealthycontrolswereperformedrestingstateBOLD—fMRIscanBrainfunctionwasinvestigatedbyamplitudeoflowfrequencyfluctuation(ALFF)andfunctionalconnectivity(FC)analy

3、sisinbothtwogroupsResult3lpatientswithSGEand30healthycontrolsfinishedtheMRIscanAfterexcluding6databecauseofheadmovement，26patientsand29healthycontrols’datawasfinallyanalyzed1ALFFanalysis：Comparedwithcontrols，SGEpatientss

4、howedsignificantlyincreasedALFFinleftinferiortemporalgyms，leftparahippocampalgyms，leftcorpuscallosum，leftprecentralgyms，leftparietalandrightfrontallobe；regionswhoseALFFdecreasedinclude：fightlingualgyms，leftcuneus，rightmi

5、ddleoccipitalgymsandfightprecuneus2FCwascalculatedwithROIoftheprecentralgymsPatientswithSGEshowedsignificantlyincreasedfunctionalconnectivityinrightmiddlefrontalgyrusanddecreasedfunctionalconnectivityinrightprecuneusConc

6、lusion1TherestingstatefMRIstudyshowedwidelydysfunctionnetworkinSGEgroup2ALFFhastheabilitytodetectepilepticactivity3TheabnormalofmiddlefrontalgyrusandprecuneusmaybemostimportantpathologybasisinSGEKEYWORDSsecondarygenerali