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1、山東中醫(yī)藥大學(xué)碩士學(xué)位論文逍遙滴鼻液對偏頭痛的中止性治療作用研究姓名：胡懷強申請學(xué)位級別：碩士專業(yè)：中醫(yī)內(nèi)科學(xué)指導(dǎo)教師：王新陸20050420TheStudyofTerminatingTherapeuticalEffectofXiaoyaonosedribblingliquidOilMigraineSpeciality：ClinicalstudyofdiseaseofnervoussystemofTCMTutor：ProWANGXin1
2、uAuthor：HUHuai—qiangAbstractObjective：TostudytheterminatingtherapeuticaleffectofXiaoyaonosedribblingliquidonmigraine，andexploreitsactionmechanismMethods：Clinicalstudywasbasedontheclinicalstudyinstructionaldoctrineofthetr
3、aditionalChinesemedicalnewdrugcuringmigraineWeselected126patientswhowererandomlydividedintocontrolgroupandtreatmentgroup，andobservedtheheadachesymptom，followingsymptoms，hemorheologyandTCD；Wistarratswereapplicatedintheexp
4、erimentalstudy，andcreatedthemigrainemodelbysubeutantaneousinjectionofnitroglycerinWeobservedthebehaviorsymptomandCfosgeneexpressioninbrainstemandhypothalamusofthemResults：Theclinicaltotalefficiencyis9333％intreatmentgroup
5、and1833％incontrolgroup，thereissignificantdifferencebetweenthem(尸001)Theheadacheandfollowingsymptomsofthepatientsintreatmentgroupwereremarkablyimpmvedinshorttime，andtheirhemorheologyandTCDweretakenanobviousturnaswellTheex
6、perimentalstudieshaveprovedthattheXiaoyaonosedribblingliquidCanquicklyterminatemigraineattackandsignificantlyanti—expressCfosinbrainsternandhypothalamusConclusions：Xiaoyaonosedribblingliquidhasextremelypreciselytherapeut
7、icaleffect，moreover，itCanfasttakeseffectandhascertainactionmechanismsThestudyachievementsprovidenewthou【ghtwaysandmethodsKeyWordsXiaoyaonosedribblingliquidmigraine；intranasaladministration；clinicalstudy；expefimentalstudy
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