強(qiáng)化運(yùn)動訓(xùn)練對腦缺血再灌注大鼠神經(jīng)功能恢復(fù)及Kalirin-7表達(dá)的影響.pdf_第1頁
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1、分類號：R493.2密級：不保密UDC：610學(xué)校代碼：11065碩士學(xué)位論文強(qiáng)化運(yùn)動訓(xùn)練對腦缺血再灌注大鼠神經(jīng)功能恢復(fù)及Kalirin7表達(dá)的影響高晶晶強(qiáng)化運(yùn)動訓(xùn)練對腦缺血再灌注大鼠神經(jīng)功能恢復(fù)及Kalirin7表達(dá)的影響高晶晶指導(dǎo)教師王強(qiáng)教授學(xué)科專業(yè)名稱康復(fù)醫(yī)學(xué)與理療學(xué)論文答辯日期2015525Effectsofintensivetreadmilltrainingonneurologicalfunctionexpressionofk

2、alirin7aftercerebralischemiareperfusioninratsAbstractObjectiveToinvestigatetheeffectsoftreadmilltrainingatdifferentdoseonneurologicalfunctionexpressionofkalirin7aftercerebralischemiareperfusioninratstoidentifythepossible

3、mechanismunderpinningtheneuralbenefitsofintensivetraininginratsaftercerebralischemiareperfusion.MethodsToestablishanimalmodelofcerebralischemiareperfusiondlecerebralarteryocclusion(MCAO)usingintraluminalthreadwasperfmedo

4、ntheleftsideinrats.45maleMCAOmodelratswereromlydividedinto3groupsincludingMCAOmodelgroupcommontraininggroupintensivetraininggroup(15ratsineachgroup).Another15ratssubjectedtoshamoperationwereassignedtobeinshamgroup.Eachof

5、the4groupswasromlydividedinto3subgroupsincluding3d7d14dsubgroups.MCAOmodelgroupshamgroupdidnomottrainingcommontraininggroupdidtreadmilltrainingoncedailyintensivetraininggroupdidtreadmilltrainingtwiceaday.Neurologicalasse

6、ssmentwasperfmedusingZausingerscesExpressionsofkalirin7kalirin7mRNAweredetectedbywesternblotRTPCR.ResultsZausingerscesofeachmottraininggroupwerehigherthanthoseofMCAOmodelgroupsatthesametimepoints(P＜0.05)At3thdaytherewasn

7、ostatisticalsignificantbetweenintensivetraininggroupcommontraininggroupinZausingerscestheexpressionofkalirin7kalirin7mRNAamongmottraininggroupsMCAOmodelgrouphadnostatisticalsignificant.At7thdayZausingerscesofintensivetra

8、ininggroupweresignificantlyhigherthanthoseofcommontraininggroup(P＜0.05)theexpressionofkalirin7ofeachmottraininggroupwassignificantlyhigherthanthatofMCAOmodelgroup(P＜0.05)intensivetraininggroupwassignificantlyhigherthanco

9、mmontraininggroup(P＜0.05)theexpressionofkalirin7mRNAofintensivetraininggroupwassignificantlyhigherthanthatofcommontraininggroup(P＜0.01).At14thdayZausingerscesofintensivetraininggroupweresignificantlyhigherthanthatofcommo

10、ntraininggroupTheexpressionofkalirin7kalirin7mRNAofeachmottraininggroupwassignificantlyhigherthanthatofMCAOmodelgroup(P＜0.05)intensivetraininggroupwassignificantlyhigherthancommontraininggroup(P＜0.05).Conclusion1.Mottrai

11、ningcanimprovetheinjuredneurologicalfunctionofratsafterdlecerebralarteryocclusion(MCAO)Ofallthetraininggroupsintensivetraininggroupobtainedthebesteffects.2.Mottrainingcanincreasetheexpressionofkalirin7kalirin7mRNAwhichpo

12、intoutthatmottrainingcanaffectthereshapingprocessofbrainbyincreasingsynapsefmationthuscanimprovetheinjuredneurologicalfunctionintensivetraininggroupobtainedthebesteffects.【Keywds】CerebralischemiareperfusionIntensivetrain

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