Caveolin-1在口腔鱗癌中的表達(dá)及其臨床意義的研究.pdf

1、潛：。R78：醉塞兩‰一1106；毒量大季碩士學(xué)位論文CaveoIin—I在II胙鱗蛸巾的表達(dá)眨H臨床意義的∞f究指導(dǎo)教師學(xué)科專業(yè)名稱玲矗提采日期晗文譽(yù)辯日期答辯委自會(huì)王席出云橙ExpressionofCaveolin1proteinanditsClinicalsingnificanceinOralSquamousCellCarcinomaAbstractobjective：Inordertoexplorebetweentheexpre

2、ssionofcaveollnIandclldicopatboiogicalsignificanceinoralsquamouscellcare]noma，Caveolin1wasdetectedinoralsquamonscellcarcinomaMotheds：Cavcolin1expressionwasdetectedin78ca∞soforalsquamouscellcarcinomaand40casesofnormaloral

3、mcosausingSABCimmunohistochemistryTheclinicalandpathologicaldataofthepatientswerecollectedandusedtomakestatisticalanalysisResults：Bothinthecaveolinlpositivetumorsandinthenormaloralmucosathecaveolin1proteinwaslocalizedint

4、hecellmembraneand／orcytoplasmThepositiveofcavcolin1expressionwas7564％ogn8)inoralsquamouscellcarcinoma，whilethenormaloralmcosahadlowercaveolin1expression(750％，p0001)Thepositiveratesofcaveolin1expressioninthegradeI，Ⅱ、IⅡofo

5、ralsquanouscellcarcinomawere4762％、7917％、9090％，respectivelywhichhadasignificantd碾刪ce(p0JD5)Thepositiveratesofcaveolin1expressioninstagesI～I(xiàn)I、Ⅲ～Ⅳw∞6389％、8571％，respectivelywhichhadasignificantdifferenceO‘005)Inadditionlymph

6、nodemetastasiswaspresentin4407％ofcaveolinl()primaryoralsquamouBcellcarcinomabutonlyin526％ofcaveofin1()prim=yoralsquamonscellcareinoma(p0OnNorelationwasfoundboththeexpressionofcaveolin1and刪血∞pan詞ogicfactolsincludinggender

7、age，growthpatternsiteRemarkablyhighdegreeexpressionofcaveolin1proteinwasobservedinoralsquamouscellc鋤[ci咖釓andthepoorlydifferentiatedoralsquamonscellcarcinomashowedthehighestpositiverateConclusions：Oralsquamonscellcarcinom

8、aoverexprossedcaveolin1andtheincreasedcaveolin1proteinexpressionmightplayacertainroleintheprogressionofmaUgn∞t均刪：Theexpressionofcaveolin1proteinhas啦畫血舳nnycorrelationwiththepathologicgradesclinicstageandlymphnodemetastasi