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1、青島大學(xué)碩士學(xué)位論文B7H4、CA及P53在上皮性卵巢癌中的表達(dá)及意義姓名:孔凡榮申請(qǐng)學(xué)位級(jí)別:碩士專業(yè):婦產(chǎn)科學(xué)指導(dǎo)教師:戴淑真王黎明20090530StudiesofB7一H4,CAl25andP53、SExpressioninEpithelialOvarianCancerandTheirClinicalValueObjective:ToinvestigatetheexpressionoftheB7一H4,CA125andP53in

2、primaryepithelialovariancancer(EpithelialOvarianCancerEOC)andtheirrelationship,嬲wellastherelationtoclinicalorpathologicalfactorsofepithelialovariancancerMethods:TheexpressionofB7H4,CAl25andP53weredeterminedbyPV6000two—st

3、epimmunohistochemistryin70casesofepithelialovariancancer20casesofnormalovariantissueand20casesofbenignovariantumorToanalyzetheexpressionoftheB7H4,CA125andP53inprimaryepithelialovariancancerandtheirrelationshipthroughPear

4、sonchisquaretest,F(xiàn)isher、sexacttest,KruskalWallisHandSpearmancorrelationsKaplanMeierandCoxRegressionwereusedtosurvivalanalysisofwasepithelialovarianCallCeLResult:ThepositiverateofB7H4inepithelialovariancancelswas885%(62/7

5、0),anditwassignificantlyhigherthaninbenignovarianepithelialtumors(45%)andnormalovariantissue(0%)ThepositiverateofCAl25inepithelialovariancancerswas771%,anditpositivelycorrelatedwithB7H4ThepositiverateofP53inepithelialova

6、riancancerwas686%(48/70),significantlylowerthanB7H4(PO05)TheB7一H4’sexpressioninepithelialovariancancerwascorrelatewithovariancancers’differentiation,histologicalcategoryandwhetherwithlymphnodemetastasisornotMultivariateC

7、OXregressionanalysisshowedthatprognosisofepithelialovariancancerswerecorrelatedwithFIGO(InternationalFederationofGynecologyandObstetrics)stage,residualtumorsize,B7H4’spositiveexpressioncelldifferentiation,CAl25’spositive

8、expression,P53’spositiveexpressionandwhetherlymphnodemetastasisornotSinglefactorKaplanMeieranalysisshowedthattheintensityofB7一H4positiveexpressionisnegativelycorrelatedwiththeaveragesurvivaltimeforpatientsandthecumulativ

9、efiveyearsurvivalratesConclusion:B7H4overexpressinepithelialovariancancerandpositivelycorrelateswithCAl25’sexpressionandhigherthanP53’sexpressionThelowercelldifferentiationofepithelialovariancancerthehigherofB7一H4’sexpre

10、ssion,andtheB7H4’sexpressioninovarianmucoidadenocarcinomaissUongerthanotherhistologicalcategoriesepithelialovariancancerB7H4isanindependentriskfactoroftotallifespanofepithelialovariancancerpatientsThes訂ongerofB7一H4’sexpr

11、essiontheshorterofaveragelifetime,andthelowerofcumulativefiveyearsurvivalrateB7一H4shouldbefurtherinvestigatedasapotentialdiagnosticandprognosticmarkerforovariancancerandshouldbemoresensitiveandmorespecificcamparetoCA125a

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