培元抗癌湯對小鼠大腸癌肝轉移模型血清中IL-12及TNF-a水平的影響.pdf

1、陜西中醫(yī)學院碩士學位論文培元抗癌湯對小鼠大腸癌肝轉移模型血清中IL12及TNFa水平的影響姓名：王乾申請學位級別：碩士專業(yè)：中西結合臨床指導教師：王建華20100401ABSTRACTEffectofCompoundPeiYuanKangAiSouponliverMetastasisinmouseModelwithColonicCancerObjective:：ToresearchtheeffectofPeiYuanKangAiSoup

2、onhepaticmetastasisofcolectalcancer，discussthemechanism.Methods：50BALBCmousedividedromlyinto5groups：modelgroup，AnKangXinCapsule(AKXC)，PeiYuanKangAiSoupgroup(largedose，dledose，lowdose)，using0.1mlCT26cellsuspension(1106ml)

3、injectintothespleenputthespleenbacktoabdominalcavity，establishthemodelofhepaticmetastasiswithcolectalcancer，nmalsodium，AnKangXinCapsule，PeiYuanKangAiSouprespectivelygiven，themetastasesdistributionoftubercleweremeasuredth

4、eexpressionofIL12TNFaweredetectedtoevaluatetheeffectofPeiYuanKangAiSoup.Results：theweightofhepaticmetastatictumwerehighersignificantly(P0.05)thanwhichofGoldenDragoncapsgroup，PeiYuanKangAiSoupgroupcomparewithmodelgroup，th

5、eweightofhepaticmetastatictumofPeiYuanKangAiSouplargedosegroupwaslowerthanthatofAnKangXinCapsul(AKXC)；theIL12TNFaexpressionweresignificantdifferenceinthefmerthreekings(P0.05).Conclusion：PeiYuanKangAiSoupcansignificantlyp

6、romotetheexpressionofIL12TNFaofcolectalcarcinomahepaticmetastasismodelofmouse，inhibitthedevelopmentofcolectalcarcinomahepaticmetastasis，wouldbeusedasameanstopreventtherecurrenceofcolectalcarcinomatotreatthehepaticmetasta