維生素d,3中間體膽固醇的分子氧氧化

1、浙江大學(xué)化學(xué)工程與生物工程學(xué)系碩士學(xué)位論文維生素D中間體膽固醇的分子氧氧化姓名：姚臻申請學(xué)位級別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：李浩然20100201AbstractVitaminD3isak_0indoffat—solublevitaminwhichplaysallessentialroleinthemaintenanceoforganicsystemsAsthepopulationagingandthedevelopmentofani

2、malhusbandrythedemandofVitarninD3willkeeprisingNowadays，someofthevitaminD3usedworldwidelyaresynthesizedusingthestrategyincludingbrominationelimination，hydrolysis，andultravioletirradiation，inwhich，theusingofalargeamountso

3、fbromineisunavoidable，therebyresultinginbromine—relatedcorrosionandenvironmentalhazardInaddition，undesiredsideproductscannotbeavoidedinthisprocessTherefore，theproductionofvitaminD3byahalogen—freemethodisvitalfortheindust

4、ryfromanenvironmentalpointofviewandhasbecomeafocusofscholasticinterestsHerein，wepresentallinnovativestrategyforthesynthesisof7keto—cholesterylacetate，whichisthekeyintermediateproductofvitaminD3OuroptimizedNhydroxyphthali

5、mide(NHPI)systemopensupanewandefficientaccesstoVitaminD3Molecularoxygenisintroducedasoxidant，andonlycatalyticamountsofNHPIisusedwinlabetteryieldwhichhasneverbeenachievedbeforeThisenvironmentallyreliableandpracticalmethod

6、holdspromisingapplicationpotentialforchemicalindustries，particularlyinthesythesisofvitaminD3，forthiseasymethodcansubstitutethebrominationinthetraditionalrouteInaddition，aplausiblereactionmechanismfortheallylicoxidationof

7、cholesterolcatalyzedbyNHPIandtransitionmetalsaltsisshowninthepaperWeexploredthemechanismbyusingelectronspinresonance(ESR)andUVvisiblespectroscopymethodsKeywords：airoxidation，VitaminD3，cholesterylacetate，7keto—cholesteryl