高錳酸鉀在有機合成中的應(yīng)用

1、河西學院化學系 2005 屆本科畢業(yè)生畢業(yè)(學位)論文第 1 頁 共 28 頁 目 錄中文摘要 ………………………………………………………………………………I ………………………………………………………………………………I英文摘要 …………………………………………………………………………II …………………………………………………………………………II第一章 KMnO4 的氧化性在有機合成中的應(yīng)用………………

2、…………………1 …………………………………1引言………………………………………………………………………………1 ………………………………………………………………………………11 KMnO4 氧化有機物的反應(yīng)特點………………………………………1 ………………………………………11.1 KMnO4 氧化的反應(yīng)機理………………………………………………1 ………………………………………………11.2 KMnO4 用量的計算………………

3、……………………………………2 ……………………………………………………21.3 溶劑的選用………………………………………………………………3 ………………………………………………………………31.4 催化劑的選用………………………………………………………………4 ………………………………………………………………41.5 反應(yīng)過程及后處理………………………………………………………4 ………………………………………………………42

4、 KMnO4 氧化在有機合成中的應(yīng)用……………………… ………………………………………………… …………………………42.1 KMnO4 氧化烷烴和烷基……………………………………………………4 ……………………………………………………42.2 KMnO4 氧化烯烴及烯基………………………………………………6 ………………………………………………62.3 KMnO4 氧化炔烴和炔基…………………………………………………10

5、…………………………………………………102.4 KMnO4 氧化芳環(huán)…………………………………………………………10 …………………………………………………………102.5 KMnO4 氧化醇類 …………………………………………………………11 …………………………………………………………112.6 KMnO4 氧化醛酮…………………………………………………………12 …………………………………………………………122.7 K

6、MnO4 與其它化合物的反應(yīng)……………………………………………13 ……………………………………………133. KMnO4 氧化有機物的研究進展…………………………………………14 …………………………………………144 參考文獻 ………………………………………………………………15 ………………………………………………………………15第二章 4,7,-二氯-5(和 6)-羧酸羅丹明熒光染料的合成研究……………17 ……………1

7、7 引言 …………………………………………………………………………17 …………………………………………………………………………171 結(jié)果和討論 …………………………………………………………………18 …………………………………………………………………182 實驗部分 ………………………………………………………………20 ………………………………………………………………203 參考文獻 …………………………………

8、………………………………21 …………………………………………………………………21附圖………………………………………………………………………………22 ………………………………………………………………………………22致謝………………………………………………………………………………28 ………………………………………………………………………………28河西學院化學系 2005 屆本科畢業(yè)生畢業(yè)(學位)論文第 3 頁 共 28 頁 Ab

9、stractChapter 1; The review of oxidation KMnO4 in application of organic synthesis Oxidation of KMnO4 as oxidant often used is one of the most general oxidation. Because of the thermal stability, the strong oxidative abi

10、lity and no easy deliquescence, it can oxide many organic compounds such as alkane, alkene, alcohol, etc.. Many chemists have demonstrated that different products are obtained under all kinds of condition. In this se

11、ction, after investgating many literatures, we reviewed the application in organic reaction of KMnO4 in detail. Recently, PTC reaction is a popular interest, which contains the property of improved rate and yield of the

12、 reaction, so it is of great value in organic synthesis. Key words Potassium Permanganate; Oxidation ; Application ; ReviewChapter 2; Synthesis of 4,7,- dichlorine -5 (and 6) - carboxylic acid Rhodamine bright fluor

13、escent dye 4,7-dichlo-5- carboxylic acid Rhodamine is a kind of bright flurescent using xanthene as scaffold, whose aryl-H was substituted with a variety of groups. Compared with any other rhodamine, they can increase or

14、 decrese emissive absorbance in most limitation. Therfore, they are widely applied to marking DNA and protein molecular acting as staining material to isolate and order DNA and protein in biology and medicine.According t

15、o Cook’s method, we attempted to synthesize 1-(2,5-dichloro-3,6-dimethy- lphenyl)ethanoneas as a key intermediate, followed by oxidation with KMnO4 to obtain 3,6-dichlorobenzene-1,2,4-tricarboxylic acid charicterized by